FBXL19 and TMEM239

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBXL19	TMEM239
Description		F-box and leucine rich repeat protein 19	transmembrane protein 239
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Membrane
	Molecular Function	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878 28135244) Mean corpuscular volume ( 27863252) Psoriasis ( 20953189 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Pulse pressure ( 27841878)	Estimated glomerular filtration rate ( 31451708) Pulse pressure ( 30224653) White matter integrity ( 23218918)
Interacting Genes		12 interacting genes: ABI1 ABI2 CBFA2T2 CREBBP DGAT2L6 EFHC2 NCK2 RPRM SORBS3 TMEM239 TRIM27 TRIM29	68 interacting genes: AQP6 ATF7 CD79A CLDN20 CLRN1 COQ8A CREB3L1 CREB3L3 CXCL16 DARS2 DCUN1D1 EBP EMP1 FAM174A FAM209A FBXL19 FFAR2 FGD2 FKBP7 FTHL17 FXYD6 GJA8 GPR101 GPR151 GPR42 LENG1 LNX1 MIEF2 MPP1 MS4A3 MTIF3 MTURN MYG1 NTAQ1 OCIAD1 ODF4 OTULIN PDCD1LG2 PNKP POLI PSCA REEP2 RETREG3 S100B SCAND1 SCN3B SDCBP SENP2 SERINC2 SLC10A1 SLC10A6 SLC18A1 SLC34A2 SLC35H1 SLC71A2 SNX1 SNX2 SPG21 SSMEM1 SYT16 TBRG4 TIMMDC1 TMEM248 TMEM31 TMX2 TRHR UBASH3A USP5
Entrez ID		54620	100288797
HPRD ID		12366
Ensembl ID		ENSG00000099364	ENSG00000198326
Uniprot IDs		H3BPZ0 H3BVB1 Q6PCT2	Q8WW34
PDB IDs		6ASB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Actin Filament Organization Actin Filament Organization Signaling Adaptor Activity SCAR Complex Actin-based Cell Projection Positive Regulation Of Actin Nucleation Filopodium Tip Regulation Of Actin Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cytoskeletal Anchor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Actin Nucleation Supramolecular Fiber Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Lamellipodium Organization Positive Regulation Of Cellular Component Organization Actin Polymerization Or Depolymerization P53 Binding Histone H3K27 Acetyltransferase Activity Filopodium Zonula Adherens Assembly Negative Regulation Of Macromolecule Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Acylglycerol Acyl-chain Remodeling Negative Regulation Of Biosynthetic Process Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress SH3 Domain Binding Diacylglycerol O-acyltransferase Activity Regulation Of Neuron Projection Development MRF Binding Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress	Membrane Protein Binding Retromer, Tubulation Complex Leptin Receptor Binding Bile Acid:sodium Symporter Activity
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