FBXL19

Description		F-box and leucine rich repeat protein 19
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878 28135244) Mean corpuscular volume ( 27863252) Psoriasis ( 20953189 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Pulse pressure ( 27841878)
Interacting Genes		12 interacting genes: ABI1 ABI2 CBFA2T2 CREBBP DGAT2L6 EFHC2 NCK2 RPRM SORBS3 TMEM239 TRIM27 TRIM29
Entrez ID		54620
HPRD ID		12366
Ensembl ID		ENSG00000099364
Uniprot IDs		H3BPZ0 H3BVB1 Q6PCT2
PDB IDs		6ASB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Actin Filament Organization Actin Filament Organization Signaling Adaptor Activity SCAR Complex Actin-based Cell Projection Positive Regulation Of Actin Nucleation Filopodium Tip Regulation Of Actin Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cytoskeletal Anchor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Actin Nucleation Supramolecular Fiber Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Lamellipodium Organization Positive Regulation Of Cellular Component Organization Actin Polymerization Or Depolymerization P53 Binding Histone H3K27 Acetyltransferase Activity Filopodium Zonula Adherens Assembly Negative Regulation Of Macromolecule Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Acylglycerol Acyl-chain Remodeling Negative Regulation Of Biosynthetic Process Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress SH3 Domain Binding Diacylglycerol O-acyltransferase Activity Regulation Of Neuron Projection Development MRF Binding Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
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