LHB and GNAS

Number of citations of the paper that reports this interaction (PMID 8663226)
11

Data Source:
HPRD (in vitro)

		LHB	GNAS
Gene Name		luteinizing hormone beta polypeptide	GNAS complex locus
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Transport Vesicle Dendrite Intrinsic Component Of Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Hormone Activity	Molecular_function GTPase Activity Adenylate Cyclase Activity Signal Transducer Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Progesterone Biosynthetic Process Signal Transduction Cell-cell Signaling Male Gonad Development Peptide Hormone Processing Cellular Protein Metabolic Process	Tissue Homeostasis Endochondral Ossification Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process DNA Methylation Water Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Female Pregnancy Blood Coagulation Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ras GTPase Activity Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Post-embryonic Body Morphogenesis Response To Drug Positive Regulation Of CAMP-mediated Signaling Small Molecule Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Intracellular Transport Developmental Growth Embryonic Cranial Skeleton Morphogenesis Regulation Of Insulin Secretion Cognition Cartilage Development Transmembrane Transport Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Genetic Imprinting Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolism of lipids and lipoproteins Mineralocorticoid biosynthesis G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Androgen biosynthesis Metabolism of steroid hormones and vitamin D Peptide hormone metabolism GPCR downstream signaling Glycoprotein hormones Peptide hormone biosynthesis	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Hedgehog 'off' state G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes G alpha (z) signalling events G alpha (i) signalling events Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor PKA activation in glucagon signalling Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding Aquaporin-mediated transport GPCR downstream signaling Platelet homeostasis Signaling by Hedgehog
Drugs
Diseases
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) DNA methylation (variation) ( 23725790) Hypertension ( 21909115) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		4 interactors: CGA GNAI2 GNAS LHCGR	31 interactors: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CRHR1 GCGR GNB1 GNGT1 HTR6 LHB LHCGR NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1
Entrez ID		3972	2778
HPRD ID		01072	00761
Ensembl ID		ENSG00000104826	ENSG00000087460
Uniprot IDs		P01229	O95467 P63092 P84996 Q5JWF2
PDB IDs		1M92
Enriched GO Terms of Interacting Partners?		Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of CAMP-mediated Signaling Regulation Of CAMP-mediated Signaling Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Cellular Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Post-embryonic Body Morphogenesis Platelet Activation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Metabolic Process Luteinizing Hormone Signaling Pathway Positive Regulation Of Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Cognition Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Regulation Of Inositol Trisphosphate Biosynthetic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Inositol Phosphate Biosynthetic Process Blood Coagulation Hemostasis Regulation Of Nitrogen Compound Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction Adrenergic Receptor Signaling Pathway Hair Follicle Placode Formation Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Signaling Regulation Of Body Fluid Levels Negative Regulation Of Multicellular Organism Growth Cellular Response To Hormone Stimulus Cell Communication Negative Regulation Of Adenylate Cyclase Activity	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Activation Of Adenylate Cyclase Activity Regulation Of Catalytic Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Energy Reserve Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Glucagon Stimulus Synaptic Transmission Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Response To Stress Response To Glucagon Response To Hormone Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Homeostatic Process Regulation Of Muscle Contraction Response To Organic Substance Renal Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Process Regulation Of Phospholipase Activity Regulation Of Blood Pressure Blood Circulation Regulation Of Signaling Vasodilation Negative Regulation Of Ion Transport Renal System Process Regulation Of Protein Kinase Activity
Tagcloud ?		action antiserum collectively dynamically exhibiting follicles follicular folliculogenesis gonad grown hcg igf1 igf1rs igf2a igf2b igf3 igfs luteinizing maturation mediating mediators oocyte reaching rescue stimulatory unexplored vertebrates zebrafish	accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields
Tagcloud (Difference) ?		action antiserum collectively dynamically exhibiting follicles follicular folliculogenesis gonad grown hcg igf1 igf1rs igf2a igf2b igf3 igfs luteinizing maturation mediating mediators oocyte reaching rescue stimulatory unexplored vertebrates zebrafish	accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields
Tagcloud (Intersection) ?