LHB and LHCGR

Number of citations: 31 (PubMedID 3470775)
Data Source: HPRD (in vivo)

		LHB	LHCGR
Name		luteinizing hormone subunit beta	luteinizing hormone/choriogonadotropin receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Lumen Pituitary Gonadotropin Complex	Endosome Plasma Membrane Membrane Centriolar Satellite
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding	G Protein-coupled Receptor Activity Luteinizing Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding
	Biological Process	Progesterone Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Male Gonad Development Hormone-mediated Signaling Pathway	Ovarian Follicle Development Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Ovulation Cycle Process Male Genitalia Development Cellular Response To Hormone Stimulus Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Gonadotropin Luteinizing Hormone Signaling Pathway Development Of Secondary Male Sexual Characteristics Cognition Uterus Development Cellular Response To Gonadotropin Stimulus Cellular Response To Luteinizing Hormone Stimulus Seminiferous Tubule Development Regulation Of Steroid Hormone Biosynthetic Process
Pathways		Androgen biosynthesis Mineralocorticoid biosynthesis Glycoprotein hormones Hormone ligand-binding receptors G alpha (s) signalling events Reactions specific to the complex N-glycan synthesis pathway	Hormone ligand-binding receptors G alpha (s) signalling events
Drugs		None	Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin Chorionic Gonadotropin (Human)
Diseases		None	Premature ovarian failure Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Body mass index ( 28892062 ) Hip circumference adjusted for BMI ( 34021172 ) Laterality in neovascular age-related macular degeneration ( 28775256 ) Polycystic ovary syndrome ( 21151128 22885925 ) Sex hormone-binding globulin levels ( 22829776 ) Triglyceride levels ( 32154731 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		7 interacting genes: CGA FHL3 GNAI2 GNAS LHCGR NTM SGTB	11 interacting genes: ARRB2 CANX CGA CGB3 CHST9 GIPC1 GNAI2 GNAS LHB NHERF1 TSHR
Entrez ID		3972	3973
HPRD ID		01072	01073
Ensembl ID		ENSG00000104826	ENSG00000138039
Uniprot IDs		A0A0F7RQE6 P01229	P22888
PDB IDs		Not available	7FIG 7FIH 7FII 7FIJ
GO Terms Enriched among Interactors		Guanyl Nucleotide Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Ovulation Cycle Process G Protein-coupled Receptor Signaling Pathway Cellular Response To Hormone Stimulus Choriogonadotropin Hormone Binding Choriogonadotropin Hormone Receptor Activity Luteinizing Hormone Receptor Activity Regulation Of Steroid Biosynthetic Process Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Negative Regulation Of Developmental Growth Regulation Of Steroid Metabolic Process Follicle-stimulating Hormone Complex Mu-type Opioid Receptor Binding Luteinizing Hormone Signaling Pathway TRC Complex Regulation Of Hormone Levels Renal System Process Pituitary Gonadotropin Complex Follicle-stimulating Hormone Signaling Pathway Animal Organ Development Gonad Development Development Of Secondary Male Sexual Characteristics Luteinizing Hormone Secretion Response To Hormone Hormone-mediated Signaling Pathway Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Hair Follicle Placode Formation Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Cellular Response To Luteinizing Hormone Stimulus Regulation Of Inositol Trisphosphate Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Gonadotropin Secretion Regulation Of Lipid Biosynthetic Process Reproductive Structure Development Beta-2 Adrenergic Receptor Binding Development Of Secondary Sexual Characteristics D1 Dopamine Receptor Binding Response To Luteinizing Hormone Negative Regulation Of Growth Rhythmic Process Positive Regulation Of Urine Volume	Pituitary Gonadotropin Complex G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Signaling Regulation Of Biological Quality Cell Communication Hormone Activity Guanyl Nucleotide Binding Renal System Process Secretion By Cell G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway Signal Transduction Heterotrimeric G-protein Complex Hormone Metabolic Process Regulation Of Hormone Levels Hormone Biosynthetic Process Postsynaptic Signal Transduction Acidic Amino Acid Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Thyrotropin-releasing Hormone Renal Phosphate Ion Absorption Regulation Of ERK1 And ERK2 Cascade Angiotensin Receptor Binding G Protein-coupled Receptor Binding Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Cellular Response To Hormone Stimulus Follicle-stimulating Hormone Complex Mu-type Opioid Receptor Binding Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Negative Regulation Of Developmental Growth Positive Regulation Of Synaptic Transmission, Dopaminergic Golgi Lumen Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis