LHB and LHCGR

Number of citations of the paper that reports this interaction (PMID 3470775)
6

Data Source:
HPRD (in vivo)

		LHB	LHCGR
Gene Name		luteinizing hormone beta polypeptide	luteinizing hormone/choriogonadotropin receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Hormone Activity	Luteinizing Hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding
	Biological Process	Progesterone Biosynthetic Process Signal Transduction Cell-cell Signaling Male Gonad Development Peptide Hormone Processing Cellular Protein Metabolic Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Activation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Male Gonad Development Male Genitalia Development Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Luteinizing Hormone Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Cognition Cellular Response To Gonadotropin Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolism of lipids and lipoproteins Mineralocorticoid biosynthesis G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Androgen biosynthesis Metabolism of steroid hormones and vitamin D Peptide hormone metabolism GPCR downstream signaling Glycoprotein hormones Peptide hormone biosynthesis	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin
Diseases
GWAS			Polycystic ovary syndrome ( 22885925 21151128) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		4 interactors: CGA GNAI2 GNAS LHCGR	11 interactors: ARRB2 CANX CGA CGB CHST9 GIPC1 GNAI2 GNAS LHB SLC9A3R1 TSHR
Entrez ID		3972	3973
HPRD ID		01072	01073
Ensembl ID		ENSG00000104826	ENSG00000138039
Uniprot IDs		P01229	P22888
PDB IDs		1M92	1LUT 1XUL
Enriched GO Terms of Interacting Partners?		Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of CAMP-mediated Signaling Regulation Of CAMP-mediated Signaling Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Cellular Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Post-embryonic Body Morphogenesis Platelet Activation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Metabolic Process Luteinizing Hormone Signaling Pathway Positive Regulation Of Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Cognition Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Regulation Of Inositol Trisphosphate Biosynthetic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Inositol Phosphate Biosynthetic Process Blood Coagulation Hemostasis Regulation Of Nitrogen Compound Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction Adrenergic Receptor Signaling Pathway Hair Follicle Placode Formation Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Signaling Regulation Of Body Fluid Levels Negative Regulation Of Multicellular Organism Growth Cellular Response To Hormone Stimulus Cell Communication Negative Regulation Of Adenylate Cyclase Activity	Cell-cell Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptide Hormone Processing Hormone Metabolic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Levels G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Peptide Metabolic Process Signal Transduction Platelet Activation Dopamine Receptor Signaling Pathway Secretion Positive Regulation Of Signal Transduction Protein Processing Cell Activation Cellular Amide Metabolic Process Hormone Biosynthetic Process Cellular Response To Stimulus Regulation Of Adenylate Cyclase Activity Regulation Of Synaptic Transmission Acid Secretion Positive Regulation Of Intracellular Signal Transduction Regulation Of Cyclase Activity Renal Phosphate Ion Absorption Post-embryonic Body Morphogenesis Regulation Of CAMP Biosynthetic Process Blood Coagulation Hemostasis Renal System Process Negative Regulation Of Sodium:proton Antiporter Activity Thyroid-stimulating Hormone Signaling Pathway Glutathione Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Multicellular Organism Growth Regulation Of CAMP Metabolic Process Protein Localization Adult Locomotory Behavior Cell Surface Receptor Signaling Pathway Secretion By Cell Protein Secretion Regulation Of Protein Kinase B Signaling Response To Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Reproductive Process
Tagcloud ?		action antiserum collectively dynamically exhibiting follicles follicular folliculogenesis gonad grown hcg igf1 igf1rs igf2a igf2b igf3 igfs luteinizing maturation mediating mediators oocyte reaching rescue stimulatory unexplored vertebrates zebrafish	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fsh fshr fshrs gonadotrophin linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Difference) ?		action antiserum collectively dynamically exhibiting follicles follicular folliculogenesis gonad grown hcg igf1 igf1rs igf2a igf2b igf3 igfs luteinizing maturation mediating mediators oocyte reaching rescue stimulatory unexplored vertebrates zebrafish	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fsh fshr fshrs gonadotrophin linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Intersection) ?