FBN1 and DCN

Number of citations of the paper that reports this interaction (PMID 10793130)
25

Data Source:
HPRD (in vivo)

		FBN1	DCN
Gene Name		fibrillin 1	decorin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Collagen Binding Glycosaminoglycan Binding Poly(A) RNA Binding Protein N-terminus Binding Extracellular Matrix Binding
	Biological Process	Skeletal System Development Metanephros Development Heart Development Extracellular Matrix Disassembly Extracellular Matrix Organization Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus	Kidney Development Placenta Development Carbohydrate Metabolic Process Skeletal Muscle Tissue Development Aging Pathogenesis Response To Mechanical Stimulus Organ Morphogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Small Molecule Metabolic Process
Pathways		Molecules associated with elastic fibres Elastic fibre formation Integrin cell surface interactions Degradation of the extracellular matrix	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Breast cancer ( 17903305) Thoracic aortic aneurysms and dissections ( 21909107)	Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		13 interactors: ATXN7 CALR DCN ELN FBLN2 FBN2 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SPRY2 VCAN	30 interactors: AHSG BRCA1 C1QA COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF WISP1
Entrez ID		2200	1634
HPRD ID		00618	00501
Ensembl ID		ENSG00000166147	ENSG00000011465
Uniprot IDs		P35555	P07585 Q6FH10
PDB IDs		1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Glycosaminoglycan Catabolic Process Organ Development Chondroitin Sulfate Metabolic Process Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Signal Transduction Dermatan Sulfate Biosynthetic Process Negative Regulation Of Signaling Striated Muscle Tissue Development Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Muscle Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Negative Regulation Of Signal Transduction System Development Chondroitin Sulfate Biosynthetic Process Glycoprotein Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Glycosaminoglycan Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Organ Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Multicellular Organismal Development Pathogenesis Skeletal System Development Anatomical Structure Development Proteoglycan Biosynthetic Process Ossification Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Developmental Process Peptide Antigen Assembly With MHC Class I Protein Complex Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sulfur Compound Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Glycoprotein Biosynthetic Process ERBB2 Signaling Pathway	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cellular Response To Amino Acid Stimulus Locomotion Movement Of Cell Or Subcellular Component Response To Amino Acid Cell Morphogenesis Involved In Differentiation Response To External Stimulus Anatomical Structure Development Axon Guidance System Development Cellular Response To Acid Chemical Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process Chemotaxis Cell Morphogenesis Collagen Fibril Organization Axonogenesis Cell Adhesion Catabolic Process Organ Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Migration Cell Projection Morphogenesis Neuron Projection Morphogenesis Platelet Activation Cell Part Morphogenesis Cellular Response To Organonitrogen Compound Tissue Development Response To Stimulus Cell Motility Cell Development Response To Stress Regulation Of Cellular Component Organization Platelet Degranulation Neuron Projection Development Regulation Of Reactive Oxygen Species Metabolic Process Cardiovascular System Development Cell Projection Organization Cell Activation Face Morphogenesis Cellular Response To Organic Substance Positive Regulation Of Cell Migration
Tagcloud ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion
Tagcloud (Difference) ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion
Tagcloud (Intersection) ?