FBN1 and ATXN7

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		FBN1	ATXN7
Gene Name		fibrillin 1	ataxin 7
Image
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Chromatin Binding Protein Binding
	Biological Process	Skeletal System Development Metanephros Development Heart Development Extracellular Matrix Disassembly Extracellular Matrix Organization Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Molecules associated with elastic fibres Elastic fibre formation Integrin cell surface interactions Degradation of the extracellular matrix	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Breast cancer ( 17903305) Thoracic aortic aneurysms and dissections ( 21909107)
Protein-Protein Interactions		13 interactors: ATXN7 CALR DCN ELN FBLN2 FBN2 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SPRY2 VCAN	59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF
Entrez ID		2200	6314
HPRD ID		00618	06365
Ensembl ID		ENSG00000166147	ENSG00000163635
Uniprot IDs		P35555	O15265 Q9UPD8
PDB IDs		1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86	2KKR
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Glycosaminoglycan Catabolic Process Organ Development Chondroitin Sulfate Metabolic Process Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Signal Transduction Dermatan Sulfate Biosynthetic Process Negative Regulation Of Signaling Striated Muscle Tissue Development Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Muscle Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Negative Regulation Of Signal Transduction System Development Chondroitin Sulfate Biosynthetic Process Glycoprotein Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Glycosaminoglycan Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Organ Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Multicellular Organismal Development Pathogenesis Skeletal System Development Anatomical Structure Development Proteoglycan Biosynthetic Process Ossification Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Developmental Process Peptide Antigen Assembly With MHC Class I Protein Complex Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sulfur Compound Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Glycoprotein Biosynthetic Process ERBB2 Signaling Pathway	Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process
Tagcloud ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Difference) ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Intersection) ?