FBN1 and MYOC

Number of citations of the paper that reports this interaction (PMID 11923248)
34

Data Source:
HPRD (in vitro)

		FBN1	MYOC
Gene Name		fibrillin 1	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Skeletal System Development Metanephros Development Heart Development Extracellular Matrix Disassembly Extracellular Matrix Organization Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Molecules associated with elastic fibres Elastic fibre formation Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Breast cancer ( 17903305) Thoracic aortic aneurysms and dissections ( 21909107)
Protein-Protein Interactions		13 interactors: ATXN7 CALR DCN ELN FBLN2 FBN2 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SPRY2 VCAN	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		2200	4653
HPRD ID		00618	03387
Ensembl ID		ENSG00000166147	ENSG00000034971
Uniprot IDs		P35555	Q99972
PDB IDs		1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Glycosaminoglycan Catabolic Process Organ Development Chondroitin Sulfate Metabolic Process Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Signal Transduction Dermatan Sulfate Biosynthetic Process Negative Regulation Of Signaling Striated Muscle Tissue Development Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Muscle Tissue Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Negative Regulation Of Signal Transduction System Development Chondroitin Sulfate Biosynthetic Process Glycoprotein Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Glycosaminoglycan Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Organ Morphogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Multicellular Organismal Development Pathogenesis Skeletal System Development Anatomical Structure Development Proteoglycan Biosynthetic Process Ossification Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Developmental Process Peptide Antigen Assembly With MHC Class I Protein Complex Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sulfur Compound Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Glycoprotein Biosynthetic Process ERBB2 Signaling Pathway	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin eln enhance extract fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?