RAD17 and HUS1

Number of citations of the paper that reports this interaction (PubMedID 10884395)
0

Data Source:
HPRD (in vivo)

		RAD17	HUS1
Description		RAD17 checkpoint clamp loader component	HUS1 checkpoint clamp component
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Rad17 RFC-like Complex Site Of Double-strand Break	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Checkpoint Clamp Complex Site Of Double-strand Break
	Molecular Function	Nucleotide Binding Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding Chromatin-protein Adaptor Activity	Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of DNA Replication Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Regulation Of Phosphorylation Protein Localization To Site Of Double-strand Break	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Response To Radiation Response To UV Embryo Development Ending In Birth Or Egg Hatching Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Gut microbiota alpha diversity (Shannon index) ( 33208821) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)
Interacting Genes		20 interacting genes: ATM ATR CLSPN CSNK1E CSNK2A1 CSNK2B HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SMG7 SNU13 USP20	28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ
Entrez ID		5884	3364
HPRD ID		09124	04787
Ensembl ID		ENSG00000152942	ENSG00000136273
Uniprot IDs		A0A0G2JP78 O75943	A4D2F2 O60921
PDB IDs		7Z6H 8GNN	3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Checkpoint Clamp Complex Negative Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Macromolecule Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Mitotic DNA Integrity Checkpoint Signaling Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Histone H2AXS139 Kinase Activity DNA Strand Elongation Involved In DNA Replication Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation DNA Replication Factor C Complex DNA Replication Cellular Response To Radiation Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Double-strand Break Repair DNA-templated DNA Replication Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Homologous Recombination Nucleus Response To Radiation Recombinational Repair Positive Regulation Of DNA Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle	DNA Repair Damaged DNA Binding DNA Damage Response DNA Metabolic Process Base-excision Repair Cellular Response To Stress DNA Damage Checkpoint Signaling Response To Radiation Signal Transduction In Response To DNA Damage DNA Recombination Nucleic Acid Metabolic Process Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Checkpoint Clamp Complex Mitotic Intra-S DNA Damage Checkpoint Signaling Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition DNA Replication Checkpoint Signaling Site Of Double-strand Break Oxidized Purine DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Protein Localization To Site Of Double-strand Break Response To Stress Mismatched DNA Binding Chromosome Organization Response To Ionizing Radiation Negative Regulation Of Cell Cycle Single Guanine Insertion Binding Dinucleotide Insertion Or Deletion Binding Base-excision Repair, Gap-filling Nucleoplasm Chromosome, Telomeric Region Guanine/thymine Mispair Binding Intracellular Signal Transduction Chromatin-protein Adaptor Activity Protein Localization To Chromosome Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Recombinational Repair Regulation Of Cell Cycle Process Maintenance Of DNA Repeat Elements MutLalpha Complex Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To UV Nucleus Enzyme Binding Depyrimidination
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