RAD17 and RFC3

Number of citations of the paper that reports this interaction (PMID 14605214)
124

Data Source:
BioGRID (pull down)

		RAD17	RFC3
Gene Name		RAD17 homolog (S. pombe)	replication factor C (activator 1) 3, 38kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm	Nucleus Nucleoplasm DNA Replication Factor C Complex
	Molecular Function	Protein Binding ATP Binding	DNA Binding DNA Clamp Loader Activity Protein Binding ATPase Activity
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Replication Regulation Of Phosphorylation	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Response To Organophosphorus
Pathways		G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints	Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER) Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Alzheimer's disease ( 20061627) Obesity-related traits ( 23251661)
Protein-Protein Interactions		16 interactors: ATM ATR HUS1 MCM7 NHP2L1 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 RFC5 USP20	9 interactors: ARFGAP1 BRD4 CHTF18 CHTF8 MESDC2 PCNA RAD17 RFC1 RFC4
Entrez ID		5884	5983
HPRD ID		09124	02676
Ensembl ID		ENSG00000152942	ENSG00000133119
Uniprot IDs		O75943	P40938
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Replication DNA Metabolic Process Cell Cycle Process Cellular Response To Stress DNA Recombination Telomere Maintenance Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Cell Cycle Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Checkpoint DNA-dependent DNA Replication Response To Stress Response To Ionizing Radiation Nucleobase-containing Compound Metabolic Process Cellular Response To Ionizing Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleotide-excision Repair Chromosome Organization Nitrogen Compound Metabolic Process Cellular Response To Radiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Radiation Biosynthetic Process Cellular Response To Stimulus Cellular Metabolic Process Double-strand Break Repair Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Response To Gamma Radiation Organelle Organization Negative Regulation Of Cell Cycle Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Mitotic Cell Cycle Homeostatic Process	DNA Replication Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Cell Cycle Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Process DNA Metabolic Process DNA Recombination Telomere Maintenance Mitotic Cell Cycle Cellular Response To Stress Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus DNA-dependent DNA Replication Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Repair Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Nuclease Activity Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Chromosome Organization Positive Regulation Of Deoxyribonuclease Activity Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Stress Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Leading Strand Elongation Nitrogen Compound Metabolic Process Regulation Of DNA Replication Negative Regulation Of DNA Damage Checkpoint Histone H3-K14 Acetylation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Cellular Homeostasis Methotrexate Transport Cellular Response To Stimulus Histone H4-K12 Acetylation Folic Acid Transport Telomere Maintenance Via Telomerase Mitotic Cell Cycle Phase Transition
Tagcloud ?		acetylcysteine antioxidant chk1 converted depleted driving experiencing gamma h2ax h2o2 illustrate instability intertwined micronuclei mildly mimics mn nac p400 pan peroxide promoting redox reinforce rnai ros sesn1 stressed subclass	12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc4 rfc5
Tagcloud (Difference) ?		acetylcysteine antioxidant chk1 converted depleted driving experiencing gamma h2ax h2o2 illustrate instability intertwined micronuclei mildly mimics mn nac p400 pan peroxide promoting redox reinforce rnai ros sesn1 stressed subclass	12q24 13q12 3q27 7q11 bands catalyzed chains chromosomes consisting dnas elongation epsilon hybrids locations mapped multimeric p145 p36 p37 p38 p40 panel primer processive q13 q24 rfc2 rfc4 rfc5
Tagcloud (Intersection) ?