CHD4 and RORC

Number of citations of the paper that reports this interaction (PMID 15144897)
5

Data Source:
HPRD (two hybrid, in vitro)

		CHD4	RORC
Gene Name		chromodomain helicase DNA binding protein 4	RAR-related orphan receptor C
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein Complex	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Microtubule Binding Zinc Ion Binding Nucleosomal DNA Binding	Transcription Coactivator Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Spindle Assembly	Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Xenobiotic Metabolic Process Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression T Cell Differentiation In Thymus Cellular Response To Sterol T-helper Cell Differentiation Positive Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Lymph Node Development Peyer's Patch Development Adipose Tissue Development Regulation Of Transcription Involved In Cell Fate Commitment Negative Regulation Of Thymocyte Apoptotic Process T-helper 17 Cell Differentiation
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Myopia (pathological) ( 23049088)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		17 interactors: ATM ATR CSNK2A1 EP300 HDAC1 HIST1H3A HIST3H3 IKZF4 MBD3L2 RBBP7 RNF8 RORC SMARCA4 SUMO1 TRIM27 TWIST1 XRN1	5 interactors: CHD4 EIF3I EIF4EBP1 EVI2A NCOA6
Entrez ID		1108	6097
HPRD ID		04472	04250
Ensembl ID		ENSG00000111642	ENSG00000143365
Uniprot IDs		B3KY63 F5GWX5 Q05CG6 Q14839	B6ZGS6 F1D8P6 H7BYJ4 P51449 Q6I9R9
PDB IDs		1MM2 1MM3 2EE1 2L5U 2L75	3B0W 3KYT 3L0J 3L0L
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Cellular Response To Heat ATP-dependent Chromatin Remodeling Chromosome Organization Regulation Of Viral Transcription DNA Metabolic Process Chromatin Organization Regulation Of Gene Expression, Epigenetic Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Binding RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Heat Regulation Of Cellular Response To Heat Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Rhythmic Process Cellular Metabolic Process Interaction With Symbiont Regulation Of Response To DNA Damage Stimulus Chromatin Modification Regulation Of RNA Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleosome Organization Regulation Of Viral Process Regulation Of Signal Transduction By P53 Class Mediator Histone Modification Transcription, DNA-templated Chromatin Remodeling Regulation Of Metabolic Process RNA Biosynthetic Process Response To Temperature Stimulus	Regulation Of Translational Initiation Translational Initiation IRES-dependent Translational Initiation Cap-independent Translational Initiation Regulation Of Translation Glucocorticoid Receptor Signaling Pathway Gene Expression Cytoplasmic Translational Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cytoplasmic Translation Posttranscriptional Regulation Of Gene Expression Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex TOR Signaling Labyrinthine Layer Blood Vessel Development Response To Ischemia Biosynthetic Process Translation Regulation Of Gene Expression
Tagcloud ?		1gamma aromatic caging calixarene calixarenes characterizing chromodomain disrupt finger fingers h3k9me0 h3k9me3 helicase heterochromatin homeodomain hosts hp1gamma macrocyclic nucleosome nurd phd phd2 powerful readers remodelling supramolecular tails trimethylated unmodified	1q21 3f2 approved chromosomal consists corresponds exon exons finger gamma genomic hgmw introns kb mapped mror orphan p1 polyadenylation rzr spanning splice steroid subfamily superfamily symbol syntenic tr3
Tagcloud (Difference) ?		1gamma aromatic caging calixarene calixarenes characterizing chromodomain disrupt fingers h3k9me0 h3k9me3 helicase heterochromatin homeodomain hosts hp1gamma macrocyclic nucleosome nurd phd phd2 powerful readers remodelling supramolecular tails trimethylated unmodified	1q21 3f2 approved chromosomal consists corresponds exon exons gamma genomic hgmw introns kb mapped mror orphan p1 polyadenylation rzr spanning splice steroid subfamily superfamily symbol syntenic tr3
Tagcloud (Intersection) ?		finger