NOL3

Description		nucleolar protein 3
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Sarcoplasm Sarcoplasmic Reticulum
	Molecular Function	RNA Binding Signaling Receptor Binding Death Receptor Binding Calcium Ion Binding Protein Binding Death Effector Domain Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Caspase Binding
	Biological Process	Response To Hypoxia Blood Vessel Remodeling Response To Ischemia MRNA Splice Site Recognition MRNA Processing Apoptotic Process RNA Splicing Negative Regulation Of Signal Transduction Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Muscle Atrophy Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Injury Involved In Regulation Of Muscle Adaptation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Complex Oligomerization Negative Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Novel Interacting Genes		2 novel interacting genes: DHX38 NDRG4
Interacting Genes		17 interacting genes: BAX CASP2 CASP8 CSNK2A1 ETNK2 FADD NIF3L1 POT1 SIRPA SRSF9 TERF1 TERF2IP TFPT TINF2 TRAF6 UBQLN2 VASP
Entrez ID		8996
HPRD ID		05572
Ensembl ID		ENSG00000140939
Uniprot IDs		O60936 Q5TZN6
PDB IDs		4UZ0
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Execution Phase Of Apoptosis Positive Regulation Of Telomere Maintenance Telomeric DNA Binding Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Telomere Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Tumor Necrosis Factor Receptor Binding Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Death Effector Domain Binding Telomere Assembly Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Organization Regulation Of Cellular Response To Stress Ripoptosome CD95 Death-inducing Signaling Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Death-inducing Signaling Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome Organization Chromosome, Telomeric Region Positive Regulation Of Myeloid Leukocyte Differentiation TRAIL-activated Apoptotic Signaling Pathway Telomeric D-loop Disassembly Identical Protein Binding
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