NOL3 and BAX

Number of citations of the paper that reports this interaction (PMID 15383280)
29

Data Source:
HPRD (in vivo)

		NOL3	BAX
Gene Name		nucleolar protein 3 (apoptosis repressor with CARD domain)	BCL2-associated X protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrion Cytosol Sarcoplasm	Nucleus Nuclear Envelope Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Pore Complex Extracellular Vesicular Exosome Bcl-2 Family Protein Complex BAX Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Caspase Binding	Protein Binding Lipid Binding Channel Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding
	Biological Process	Response To Hypoxia MRNA Splice Site Selection RNA Splicing Response To Injury Involved In Regulation Of Muscle Adaptation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Oligomerization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Ovarian Follicle Development Neuron Migration T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Germ Cell Development Mitochondrial Fusion Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Apoptotic Mitochondrial Changes Fertilization Response To Toxic Substance Response To Salt Stress Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Viral Process Hypothalamus Development Cerebral Cortex Development Negative Regulation Of Protein Binding Positive Regulation Of Protein Oligomerization Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Within A Tissue Protein Oligomerization Protein Homooligomerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Mitochondrion Morphogenesis Cellular Response To Organic Substance Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Retinal Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Activation, translocation and oligomerization of BAX Programmed Cell Death Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: BAX CASP2 CASP8 CSNK2A1 ETNK2 FADD NIF3L1 POT1 SIRPA SRSF9 TERF1 TERF2IP TFPT TINF2 VASP	25 interactors: BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BID BNIPL ERN1 KCNA3 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 SNCA UHRF2 VDAC1 YWHAB YWHAQ ZBTB24
Entrez ID		8996	581
HPRD ID		05572	02498
Ensembl ID		ENSG00000140939	ENSG00000087088
Uniprot IDs		B4DFL0 O60936 Q5TZN6	Q07812
PDB IDs			1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Positive Regulation Of Organelle Organization Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Chromosome Organization Regulation Of Cysteine-type Endopeptidase Activity RNA-dependent DNA Replication Negative Regulation Of DNA Metabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Cell Death Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of DNA Replication Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Peptidase Activity Protein Oligomerization Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Assembly Telomere Assembly Regulation Of Lymphocyte Apoptotic Process Regulation Of Cellular Component Organization Protein Processing Cellular Response To Mechanical Stimulus Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Telomerase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Telomere Maintenance Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Macrophage Differentiation Cell Death Activation Of Cysteine-type Endopeptidase Activity Death	Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Release Of Cytochrome C From Mitochondria Mitochondrion Organization Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Mitochondrial Membrane Permeability Regulation Of Signaling Positive Regulation Of Intracellular Transport Regulation Of Membrane Permeability Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Endopeptidase Activity Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Regulation Of Peptidase Activity Regulation Of Mitochondrial Membrane Potential Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		bak1 birc2 birc3 c57bl cgy eosin evident gamma greatest gy hematoxylin irradiated ldr livers mcl1 modified nearly phagocytosis proton protons radiation radical ray rays regimen sections stained strikingly traf3	androgen bad bak colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Difference) ?		bak1 birc2 birc3 c57bl cgy eosin evident gamma greatest gy hematoxylin irradiated ldr livers mcl1 modified nearly phagocytosis proton protons radiation radical ray rays regimen sections stained strikingly traf3	androgen bad bak colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
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