MAGOHB and EFHC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGOHB	EFHC2
Description		mago homolog B, exon junction complex subunit	EF-hand domain containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Exon-exon Junction Complex Neuronal Cell Body U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14	Cytoplasm Cytoskeleton Microtubule Axonemal Microtubule Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	RNA Binding Protein Binding	Calcium Ion Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus RNA Splicing Regulation Of MRNA Processing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Regulation Of Neuron Projection Development Flagellated Sperm Motility Cellular Response To Leukemia Inhibitory Factor
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Glaucoma (primary open-angle) ( 33627673) Mean arterial pressure ( 29403010)
Interacting Genes		74 interacting genes: ADAMTSL4 AMOTL2 BEND7 C18orf54 CALCOCO2 CARD10 CCDC102B CCDC106 CCDC33 CEBPA DVL2 DVL3 EFHC2 FHL5 FXR1 GNPDA2 GOLGA2 GPANK1 HMG20A HSF2BP IHO1 IKZF1 IKZF3 INCA1 KRT40 KRT75 KRTAP1-1 KRTAP13-2 MID2 NDUFB7 PARD6B PAX7 PBX4 PKP2 PRPH PRPSAP1 PTPN21 RBAK RBM8A RBMX REL RUNDC3A SNW1 SPATA6 SPDYE4 STX11 TADA2A TCF4 TERF2 TERF2IP THAP7 TLE5 TRA2A TRA2B TRIM27 TRIM42 YWHAG ZBTB10 ZBTB42 ZFP14 ZFYVE1 ZNF19 ZNF250 ZNF398 ZNF426 ZNF438 ZNF446 ZNF449 ZNF547 ZNF566 ZNF57 ZNF620 ZNF774 ZNF835	100 interacting genes: - AASDHPPT ARHGEF5 ARMC7 ATOSB CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MTCL2 MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 USP2 ZBTB16 ZFHX3 ZZZ3
Entrez ID		55110	80258
HPRD ID		08544	06540
Ensembl ID		ENSG00000111196	ENSG00000183690
Uniprot IDs		F5H6P7 Q96A72	Q5JST6
PDB IDs		5XJC 5YZG 6ICZ 6QDV	2Z13 2Z14 7UNG 8J07
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process Zinc Ion Binding Regulation Of Macromolecule Biosynthetic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleus Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of RNA Splicing Identical Protein Binding Intermediate Filament Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomeric DNA Binding Intermediate Filament Organization Regulation Of MRNA Processing Shelterin Complex Protection From Non-homologous End Joining At Telomere Positive Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Positive Regulation Of Neuron Projection Arborization Positive Regulation Of RNA Metabolic Process Nuclear Telomere Cap Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament G-rich Strand Telomeric DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Localization To Chromosome, Telomeric Region Spliceosomal Complex Regulation Of RNA Splicing Telomere Capping Metal Ion Binding Telomere Maintenance In Response To DNA Damage	Cytoplasm Protein Binding Protein Phosphorylation Cytoskeleton Regulation Of Podosome Assembly Phosphorylation Centrosome
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