POLH and DYNLL1

Number of citations of the paper that reports this interaction (PMID 14760703)
24

Data Source:
HPRD (in vitro)

		POLH	DYNLL1
Gene Name		polymerase (DNA directed), eta	dynein, light chain, LC8-type 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA Repair Regulation Of DNA Repair Pyrimidine Dimer Repair Postreplication Repair Response To UV-C	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template Translesion synthesis by Pol eta	Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP DYNLL1 PCNA POLI REV1 RPS27A UBC	77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A
Entrez ID		5429	8655
HPRD ID		04913	03334
Ensembl ID		ENSG00000170734	ENSG00000088986
Uniprot IDs		B4DG64 Q9Y253	P63167 Q6FGH9
PDB IDs		2I5O 2LSK 3MR2 3MR3 3MR5 3MR6 3SI8 3TQ1 4DL2 4DL3 4DL4 4DL5 4DL6 4DL7 4ECQ 4ECR 4ECS 4ECT 4ECU 4ECV 4ECW 4ECX 4ECY 4ECZ 4ED0 4ED1 4ED2 4ED3 4ED6 4ED7 4ED8 4EEY 4J9K 4J9L 4J9M 4J9N 4J9O 4J9P 4J9Q 4J9R 4J9S	1CMI 3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway DNA Repair Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of ERBB Signaling Pathway DNA Biosynthetic Process DNA Metabolic Process Translesion Synthesis Viral Protein Processing G2/M Transition Of Mitotic Cell Cycle Notch Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Postreplication Repair Notch Receptor Processing Virion Assembly Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Mitotic Cell Cycle Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Nitrogen Compound Metabolic Process DNA Replication Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Cell Cycle Response To Stress Antigen Processing And Presentation Positive Regulation Of Proteolysis Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of ERBB Signaling Pathway Macromolecule Biosynthetic Process Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Apoptotic Signaling Pathway Toll-like Receptor 5 Signaling Pathway	Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process
Tagcloud ?		atypical au element encoding eta half knockdown markedly owing pcbp1 pigmentosum poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Difference) ?		atypical au element encoding eta half knockdown markedly owing pcbp1 pigmentosum poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Intersection) ?