POLH and PCNA

Number of citations of the paper that reports this interaction (PMID 11585903)
73

Data Source:
HPRD (two hybrid, in vitro)

		POLH	PCNA
Gene Name		polymerase (DNA directed), eta	proliferating cell nuclear antigen
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Nucleoplasm DNA Replication Factor C Complex Cytoplasm Centrosome Nuclear Replication Fork PCNA Complex Extracellular Vesicular Exosome PCNA-p21 Complex
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Identical Protein Binding DNA Polymerase Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA Repair Regulation Of DNA Repair Pyrimidine Dimer Repair Postreplication Repair Response To UV-C	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Regulation Of DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Heart Development Cell Proliferation Translesion Synthesis Epithelial Cell Differentiation Positive Regulation Of Deoxyribonuclease Activity Telomere Maintenance Via Semi-conservative Replication Response To Lipid Response To Cadmium Ion
Pathways		DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template Translesion synthesis by Pol eta	Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance G1/S Transition Removal of DNA patch containing abasic residue G1/S-Specific Transcription Resolution of Abasic Sites (AP sites) Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Base Excision Repair E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand G0 and Early G1 Telomere C-strand (Lagging Strand) Synthesis S Phase Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP DYNLL1 PCNA POLI REV1 RPS27A UBC	116 interactors: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 EXO1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HLTF HUS1 ING1 KCTD13 LDHA LIG1 MCL1 MLH1 MSH2 MSH3 MSH6 MUTYH MYBBP1A PARP1 PARP10 PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLL POLM PPP1CA PRKDC PTMA RAD18 RAD9A RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RNF8 RPA1 SEC23IP SETD8 SHPRH SIVA1 SMARCAD1 SPRTN SUB1 TCOF1 TDG TIRAP TMEM218 TPI1 UBB UBE2A UBE2B UBE2D3 UHRF2 UNG USP1 USP2 USP4 WDR48 WRN XRCC1 XRCC5 XRCC6 YBX1 ZBTB1
Entrez ID		5429	5111
HPRD ID		04913	01456
Ensembl ID		ENSG00000170734	ENSG00000132646
Uniprot IDs		B4DG64 Q9Y253	P12004
PDB IDs		2I5O 2LSK 3MR2 3MR3 3MR5 3MR6 3SI8 3TQ1 4DL2 4DL3 4DL4 4DL5 4DL6 4DL7 4ECQ 4ECR 4ECS 4ECT 4ECU 4ECV 4ECW 4ECX 4ECY 4ECZ 4ED0 4ED1 4ED2 4ED3 4ED6 4ED7 4ED8 4EEY 4J9K 4J9L 4J9M 4J9N 4J9O 4J9P 4J9Q 4J9R 4J9S	1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3P87 3TBL 3VKX
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway DNA Repair Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of ERBB Signaling Pathway DNA Biosynthetic Process DNA Metabolic Process Translesion Synthesis Viral Protein Processing G2/M Transition Of Mitotic Cell Cycle Notch Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Postreplication Repair Notch Receptor Processing Virion Assembly Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Mitotic Cell Cycle Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Nitrogen Compound Metabolic Process DNA Replication Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Cell Cycle Response To Stress Antigen Processing And Presentation Positive Regulation Of Proteolysis Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of ERBB Signaling Pathway Macromolecule Biosynthetic Process Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Apoptotic Signaling Pathway Toll-like Receptor 5 Signaling Pathway	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Cell Cycle Process Chromosome Organization Base-excision Repair Cellular Metabolic Process Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Recombination Nuclear DNA Replication Mitotic Cell Cycle Mitotic Recombination Mismatch Repair Telomere Maintenance Via Telomere Lengthening DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Strand Elongation Cellular Response To Stimulus Response To Radiation Response To Stimulus Organelle Organization DNA-dependent DNA Replication Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To UV Double-strand Break Repair Nucleotide-excision Repair Response To Abiotic Stimulus Catabolic Process Somatic Diversification Of Immunoglobulins Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Cellular Metabolic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Cycle Response To Light Stimulus Cellular Macromolecule Catabolic Process
Tagcloud ?		atypical au element encoding eta half knockdown markedly owing pcbp1 pigmentosum poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		atypical au element encoding eta half knockdown markedly owing pcbp1 pigmentosum poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?