POLH and POLI

Number of citations of the paper that reports this interaction (PMID 16763556)
54

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		POLH	POLI
Gene Name		polymerase (DNA directed), eta	polymerase (DNA directed) iota
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Intracellular Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA Repair Regulation Of DNA Repair Pyrimidine Dimer Repair Postreplication Repair Response To UV-C	DNA Replication DNA Repair DNA Biosynthetic Process
Pathways		DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template Translesion synthesis by Pol eta
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP DYNLL1 PCNA POLI REV1 RPS27A UBC	16 interactors: APP CALCOCO2 DAZAP2 DVL2 PCNA POLH REV1 RNF11 TMEM239 TRAF6 TRIM23 TRIM39 UBA52 UBB UBC ZBTB44
Entrez ID		5429	11201
HPRD ID		04913	16094
Ensembl ID		ENSG00000170734	ENSG00000101751
Uniprot IDs		B4DG64 Q9Y253	J3KQ09 Q9UNA4
PDB IDs		2I5O 2LSK 3MR2 3MR3 3MR5 3MR6 3SI8 3TQ1 4DL2 4DL3 4DL4 4DL5 4DL6 4DL7 4ECQ 4ECR 4ECS 4ECT 4ECU 4ECV 4ECW 4ECX 4ECY 4ECZ 4ED0 4ED1 4ED2 4ED3 4ED6 4ED7 4ED8 4EEY 4J9K 4J9L 4J9M 4J9N 4J9O 4J9P 4J9Q 4J9R 4J9S	1T3N 1ZET 2ALZ 2DPI 2DPJ 2FLL 2FLN 2FLP 2KHU 2KHW 2KTF 2L0F 2L0G 3EPG 3EPI 3G6V 3G6X 3G6Y 3GV5 3GV7 3GV8 3H40 3H4B 3H4D 3NGD 3OSN 3Q8P 3Q8Q 3Q8R 3Q8S 4EBC 4EBD 4EBE 4EYH 4EYI 4FS1 4FS2
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway DNA Repair Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of ERBB Signaling Pathway DNA Biosynthetic Process DNA Metabolic Process Translesion Synthesis Viral Protein Processing G2/M Transition Of Mitotic Cell Cycle Notch Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Postreplication Repair Notch Receptor Processing Virion Assembly Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Mitotic Cell Cycle Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Nitrogen Compound Metabolic Process DNA Replication Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Cell Cycle Response To Stress Antigen Processing And Presentation Positive Regulation Of Proteolysis Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of ERBB Signaling Pathway Macromolecule Biosynthetic Process Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Apoptotic Signaling Pathway Toll-like Receptor 5 Signaling Pathway	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Viral Protein Processing I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Intracellular Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of ERBB Signaling Pathway JNK Cascade Postreplication Repair Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Notch Receptor Processing Virion Assembly Negative Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Serine/threonine Kinase Activity Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of MAP Kinase Activity Glycogen Biosynthetic Process Intracellular Transport Of Virus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade DNA Repair Positive Regulation Of Catalytic Activity Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Notch Signaling Pathway Activation Of MAPK Activity Activation Of Innate Immune Response
Tagcloud ?		atypical au element encoding eta half knockdown markedly owing pcbp1 pigmentosum poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	acad accordance asp125 asp148 asp150 catalysed dideoxynucleotide discriminate enzymatically exonucleolytic exploitable gapped heteropolymer homo invariant lacked natl neutralisation nicked nuclease overproduced polymerisation predictions proc proofreading richardson tabor terminating triphosphates
Tagcloud (Difference) ?		atypical au element encoding eta half knockdown markedly owing pcbp1 pigmentosum poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	acad accordance asp125 asp148 asp150 catalysed dideoxynucleotide discriminate enzymatically exonucleolytic exploitable gapped heteropolymer homo invariant lacked natl neutralisation nicked nuclease overproduced polymerisation predictions proc proofreading richardson tabor terminating triphosphates
Tagcloud (Intersection) ?