POLH and REV1

Number of citations of the paper that reports this interaction (PMID 15189446)
57

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		POLH	REV1
Gene Name		polymerase (DNA directed), eta	REV1, polymerase (DNA directed)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleoplasm
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding	Magnesium Ion Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Deoxycytidyl Transferase Activity
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA Repair Regulation Of DNA Repair Pyrimidine Dimer Repair Postreplication Repair Response To UV-C	DNA Replication DNA Repair Response To UV Error-prone Translesion Synthesis
Pathways		DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template Translesion synthesis by Pol eta	DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template Translesion synthesis by HREV1
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		7 interactors: APP DYNLL1 PCNA POLI REV1 RPS27A UBC	8 interactors: FHL2 MAD2L2 POLDIP2 POLH POLI POLK POLL REV3L
Entrez ID		5429	51455
HPRD ID		04913	16202
Ensembl ID		ENSG00000170734	ENSG00000135945
Uniprot IDs		B4DG64 Q9Y253	Q9UBZ9
PDB IDs		2I5O 2LSK 3MR2 3MR3 3MR5 3MR6 3SI8 3TQ1 4DL2 4DL3 4DL4 4DL5 4DL6 4DL7 4ECQ 4ECR 4ECS 4ECT 4ECU 4ECV 4ECW 4ECX 4ECY 4ECZ 4ED0 4ED1 4ED2 4ED3 4ED6 4ED7 4ED8 4EEY 4J9K 4J9L 4J9M 4J9N 4J9O 4J9P 4J9Q 4J9R 4J9S	2EBW 2LSI 2LSK 2LSY 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway DNA Repair Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of ERBB Signaling Pathway DNA Biosynthetic Process DNA Metabolic Process Translesion Synthesis Viral Protein Processing G2/M Transition Of Mitotic Cell Cycle Notch Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Postreplication Repair Notch Receptor Processing Virion Assembly Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Mitotic Cell Cycle Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Nitrogen Compound Metabolic Process DNA Replication Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Cell Cycle Response To Stress Antigen Processing And Presentation Positive Regulation Of Proteolysis Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of ERBB Signaling Pathway Macromolecule Biosynthetic Process Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Apoptotic Signaling Pathway Toll-like Receptor 5 Signaling Pathway	DNA Biosynthetic Process DNA Repair DNA Replication Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Postreplication Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Nitrogen Compound Metabolic Process Nucleotide-excision Repair DNA-dependent DNA Replication Cellular Response To Stimulus Atrial Cardiac Muscle Cell Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Error-prone Translesion Synthesis Negative Regulation Of APC-Cdc20 Complex Activity Negative Regulation Of Transcription By Competitive Promoter Binding Response To Stimulus Translesion Synthesis Response To UV-C Pyrimidine Dimer Repair DNA Damage Response, Signal Transduction Resulting In Transcription Somatic Hypermutation Of Immunoglobulin Genes Heart Trabecula Formation DNA Synthesis Involved In DNA Repair Negative Regulation Of Transcription Regulatory Region DNA Binding Somatic Diversification Of Immune Receptors Via Somatic Mutation Nucleotide-excision Repair, DNA Gap Filling Ventricular Cardiac Muscle Cell Development Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription Regulatory Region DNA Binding Mitochondrion Morphogenesis Heart Trabecula Morphogenesis Ventricular Cardiac Muscle Cell Differentiation
Tagcloud ?		atypical au element encoding eta half knockdown markedly owing pcbp1 pigmentosum poly prone rc responsive rich stability sufficient suppressor tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief sensing short specialized starvation sumo2 suppressor therapies toxic turn
Tagcloud (Difference) ?		atypical au element encoding eta half knockdown markedly owing pcbp1 pigmentosum poly prone rc responsive rich stability sufficient tls transcript translesion tumour uncovered upon utr variant xeroderma xpv	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief sensing short specialized starvation sumo2 therapies toxic turn
Tagcloud (Intersection) ?		suppressor