POLD2 and XRN1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		POLD2	XRN1
Gene Name		polymerase (DNA directed), delta 2, accessory subunit	5-3 exoribonuclease 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasmic MRNA Processing Body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Intermediate Filament Cytoskeleton
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	DNA Binding Exonuclease Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Gene Expression RRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Histone MRNA Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)	Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CCHCR1 CDK2 CDKN1A EP300 KCTD13 LSM6 PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 SOX12 WRN WRNIP1 XRN1	62 interactors: ALDOA ANGPTL6 AP1G2 ATP5G2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CD97 CENPBD1 CHD4 CTSB CTSH DCP1A DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 GLMP HEATR1 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SKIV2L2 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPAL ZFP36
Entrez ID		5425	54464
HPRD ID		15982	10470
Ensembl ID		ENSG00000106628	ENSG00000114127
Uniprot IDs		A4D2J4 B2R5S4 P49005	Q8IZH2
PDB IDs		3E0J
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Base-excision Repair Telomere Maintenance Via Semi-conservative Replication Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Telomere Maintenance Via Recombination Telomere Maintenance Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Repair Mismatch Repair Chromosome Organization Cellular Response To Stress DNA Metabolic Process Mitotic Cell Cycle DNA Recombination Nucleotide-excision Repair Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization Regulation Of DNA-dependent DNA Replication Initiation Cell Cycle Response To Stress Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Macromolecule Biosynthetic Process Signal Transduction By P53 Class Mediator G2/M Transition Of Mitotic Cell Cycle Response To UV Positive Regulation Of DNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Mitochondrion Morphogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Biosynthetic Process	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RRNA Processing RNA Processing RRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Generation Of Precursor Metabolites And Energy Ribosome Biogenesis Cellular Metabolic Process Respiratory Electron Transport Chain Electron Transport Chain RNA Splicing RNA Localization RNA Export From Nucleus Gene Expression Cellular Respiration MRNA Processing Energy Derivation By Oxidation Of Organic Compounds Ribonucleoprotein Complex Biogenesis Cellular Process Nuclear MRNA Surveillance Metabolic Process Nuclear Export MRNA Transport RNA Surveillance MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process ATP Metabolic Process Dosage Compensation By Inactivation Of X Chromosome Cellular Response To Thyroid Hormone Stimulus RNA Transport RNA Destabilization Dosage Compensation MRNA Export From Nucleus Posttranscriptional Regulation Of Gene Expression
Tagcloud ?			alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2
Tagcloud (Difference) ?			alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2
Tagcloud (Intersection) ?