POLD2 and POLDIP3

Number of citations of the paper that reports this interaction (PMID 12522211)
17

Data Source:
HPRD (two hybrid)

		POLD2	POLDIP3
Gene Name		polymerase (DNA directed), delta 2, accessory subunit	polymerase (DNA-directed), delta interacting protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Transcription Export Complex Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding	Nucleotide Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Poly(A)+ MRNA Export From Nucleus Positive Regulation Of Translation
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CCHCR1 CDK2 CDKN1A EP300 KCTD13 LSM6 PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 SOX12 WRN WRNIP1 XRN1	10 interactors: BANP ERH GOLGA2 KRT40 LZTS2 MTUS2 PNMA1 POLD2 RPS6KA1 RPS6KB1
Entrez ID		5425	84271
HPRD ID		15982	17875
Ensembl ID		ENSG00000106628	ENSG00000100227
Uniprot IDs		A4D2J4 B2R5S4 P49005	B4E0L0 Q659C6 Q9BY77
PDB IDs		3E0J
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Base-excision Repair Telomere Maintenance Via Semi-conservative Replication Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Telomere Maintenance Via Recombination Telomere Maintenance Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Repair Mismatch Repair Chromosome Organization Cellular Response To Stress DNA Metabolic Process Mitotic Cell Cycle DNA Recombination Nucleotide-excision Repair Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization Regulation Of DNA-dependent DNA Replication Initiation Cell Cycle Response To Stress Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Macromolecule Biosynthetic Process Signal Transduction By P53 Class Mediator G2/M Transition Of Mitotic Cell Cycle Response To UV Positive Regulation Of DNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Mitochondrion Morphogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Biosynthetic Process	Cell Cycle Mitotic Cell Cycle Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Tagcloud ?			a2 als altogether amyotrophic becomes cytoplasm degeneration dimerization dysregulation escaping frontotemporal ftld heterogeneous hnrnp hnrnps knocking lateral lobar localizes neurotoxic neurotoxicity normally ribonucleoprotein sclerosis shifts splicing tdp transactive u
Tagcloud (Difference) ?			a2 als altogether amyotrophic becomes cytoplasm degeneration dimerization dysregulation escaping frontotemporal ftld heterogeneous hnrnp hnrnps knocking lateral lobar localizes neurotoxic neurotoxicity normally ribonucleoprotein sclerosis shifts splicing tdp transactive u
Tagcloud (Intersection) ?