POLD2 and SOX12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		POLD2	SOX12
Description		DNA polymerase delta 2, accessory subunit	SRY-box transcription factor 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex	Chromatin Nucleus Nucleoplasm Protein-DNA Complex
	Molecular Function	DNA Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair DNA Damage Response Error-prone Translesion Synthesis DNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Brain Development Spinal Cord Development Neuron Differentiation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Camera-type Eye Morphogenesis
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS			Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)
Interacting Genes		19 interacting genes: CCHCR1 CDK2 CDKN1A EP300 ERBB2 KCTD13 LSM6 OGT PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 POLH SOX12 WRN WRNIP1 XRN1	3 interacting genes: POLD2 SMAD4 SRM
Entrez ID		5425	6666
HPRD ID		15982	09056
Ensembl ID		ENSG00000106628	ENSG00000177732
Uniprot IDs		A0A087WWF6 P49005	O15370
PDB IDs		3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
Enriched GO Terms of Interacting Partners?		DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process DNA Replication Translesion Synthesis DNA Damage Response Postreplication Repair DNA Repair Delta DNA Polymerase Complex Nucleus Nucleobase-containing Compound Biosynthetic Process DNA-directed DNA Polymerase Activity Error-free Translesion Synthesis Response To UV Cellular Response To Radiation Regulation Of DNA Metabolic Process DNA Metabolic Process Cellular Response To UV Macromolecule Biosynthetic Process Cellular Response To Light Stimulus Positive Regulation Of DNA Replication Cellular Response To Stress Regulation Of DNA Replication Nucleic Acid Metabolic Process DNA-templated DNA Replication Nucleoplasm Damaged DNA Binding Response To Light Stimulus Chromosome, Telomeric Region PCNA-p21 Complex Nucleobase-containing Compound Metabolic Process Response To Stress Replication Fork Mismatch Repair Response To Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleotide-excision Repair, DNA Gap Filling Exonuclease Activity MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication G-quadruplex DNA Binding Cellular Senescence Error-prone Translesion Synthesis Regulation Of Metabolic Process DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling Response To UV-C Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process	Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Spermidine Synthase Activity Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchyme Morphogenesis Spermidine Biosynthetic Process SMAD Protein Complex Positive Regulation Of Luteinizing Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Sebaceous Gland Development Heteromeric SMAD Protein Complex Formation Of Anatomical Boundary Brainstem Development Mesendoderm Development Sulfate Binding Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Endocardial Cell Differentiation Delta DNA Polymerase Complex Zeta DNA Polymerase Complex Spermidine Metabolic Process Atrioventricular Canal Development Somite Rostral/caudal Axis Specification Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Cardiac Muscle Cell Differentiation Endothelial Cell Activation Error-prone Translesion Synthesis Cardiac Muscle Hypertrophy In Response To Stress Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Cardiocyte Differentiation Secondary Palate Development Filamin Binding Neural Crest Cell Differentiation Heart Valve Formation DNA Strand Elongation Involved In DNA Replication Polyamine Biosynthetic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process I-SMAD Binding Cardiac Conduction System Development Interleukin-6-mediated Signaling Pathway Gastrulation With Mouth Forming Second Regulation Of Cell Proliferation Involved In Heart Morphogenesis Polyamine Metabolic Process Regulation Of Cardiac Muscle Cell Differentiation
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