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POLD2 and LSM6
Number of citations of the paper that reports this interaction (PubMedID
15231747
)
47
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
POLD2
LSM6
Description
DNA polymerase delta 2, accessory subunit
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Zeta DNA Polymerase Complex
Delta DNA Polymerase Complex
P-body
Nucleus
Nucleoplasm
Spliceosomal Complex
U6 SnRNP
Nucleolus
Sno(s)RNA-containing Ribonucleoprotein Complex
Cytoplasm
Cytosol
Small Nuclear Ribonucleoprotein Complex
U4/U6 X U5 Tri-snRNP Complex
U2-type Precatalytic Spliceosome
Lsm2-8 Complex
Ribonucleoprotein Complex
Molecular Function
DNA Binding
Protein Binding
RNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
DNA Replication
DNA-templated DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
DNA Damage Response
Error-prone Translesion Synthesis
DNA Biosynthetic Process
MRNA Splicing, Via Spliceosome
RRNA Processing
MRNA Processing
MRNA Catabolic Process
TRNA Processing
RNA Splicing
Maturation Of SSU-rRNA
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
mRNA decay by 5' to 3' exoribonuclease
mRNA decay by 5' to 3' exoribonuclease
mRNA Splicing - Major Pathway
Drugs
Uridine
Uridine monophosphate
Citric acid
Diseases
GWAS
Malaria (
31844061
)
Systolic blood pressure response to hydrochlorothiazide in hypertension (
27802415
)
Interacting Genes
19 interacting genes:
CCHCR1
CDK2
CDKN1A
EP300
ERBB2
KCTD13
LSM6
OGT
PCNA
POLD1
POLD3
POLD4
POLDIP2
POLDIP3
POLH
SOX12
WRN
WRNIP1
XRN1
16 interacting genes:
APP
CEBPA
LSM1
LSM2
LSM3
LSM5
LSM7
LSM8
MCRS1
PATL1
POLD2
SDCBP
SMN1
SNRPD2
SNRPF
TARDBP
Entrez ID
5425
11157
HPRD ID
15982
06286
Ensembl ID
ENSG00000106628
ENSG00000164167
Uniprot IDs
A0A087WWF6
P49005
P62312
PDB IDs
3E0J
6S1M
6S1N
6S1O
6TNY
6TNZ
9EKB
3JCR
5O9Z
6AH0
6AHD
6QW6
6QX9
7ABG
8H6E
8H6J
8H6K
8H6L
8QO9
8QXD
8QZS
8R08
8R09
8R0A
8R0B
8RM5
Enriched GO Terms of Interacting Partners
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DNA Synthesis Involved In DNA Repair
DNA Biosynthetic Process
DNA Replication
Translesion Synthesis
DNA Damage Response
Postreplication Repair
DNA Repair
Delta DNA Polymerase Complex
Nucleus
Nucleobase-containing Compound Biosynthetic Process
DNA-directed DNA Polymerase Activity
Error-free Translesion Synthesis
Response To UV
Cellular Response To Radiation
Regulation Of DNA Metabolic Process
DNA Metabolic Process
Cellular Response To UV
Macromolecule Biosynthetic Process
Cellular Response To Light Stimulus
Positive Regulation Of DNA Replication
Cellular Response To Stress
Regulation Of DNA Replication
Nucleic Acid Metabolic Process
DNA-templated DNA Replication
Nucleoplasm
Damaged DNA Binding
Response To Light Stimulus
Chromosome, Telomeric Region
PCNA-p21 Complex
Nucleobase-containing Compound Metabolic Process
Response To Stress
Replication Fork
Mismatch Repair
Response To Radiation
Macromolecule Metabolic Process
Positive Regulation Of DNA Metabolic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleotide-excision Repair, DNA Gap Filling
Exonuclease Activity
MutLalpha Complex Binding
Telomere Maintenance Via Semi-conservative Replication
G-quadruplex DNA Binding
Cellular Senescence
Error-prone Translesion Synthesis
Regulation Of Metabolic Process
DNA Strand Elongation Involved In DNA Replication
Base-excision Repair, Gap-filling
Response To UV-C
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA Biosynthetic Process
Lsm1-7-Pat1 Complex
U4/U6 X U5 Tri-snRNP Complex
Lsm2-8 Complex
U2-type Precatalytic Spliceosome
U6 SnRNP
RNA Splicing, Via Transesterification Reactions
RNA Splicing
MRNA Metabolic Process
MRNA Processing
Nucleic Acid Metabolic Process
RNA Metabolic Process
Spliceosomal Complex
Nucleobase-containing Compound Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Processing
Ribonucleoprotein Complex
Precatalytic Spliceosome
RNA Binding
Catalytic Step 2 Spliceosome
Macromolecule Metabolic Process
Spliceosomal SnRNP Assembly
MRNA Catabolic Process
Nucleus
U6 SnRNA Binding
SMN-Sm Protein Complex
RNA Catabolic Process
Nucleoplasm
U12-type Spliceosomal Complex
P-body
Spliceosomal Complex Assembly
PICln-Sm Protein Complex
Nucleobase-containing Compound Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
7-methylguanosine Cap Hypermethylation
Poly(G) Binding
Protein-RNA Complex Assembly
Negative Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
U4 SnRNP
Methylosome
Negative Regulation Of Biosynthetic Process
Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
P-body Assembly
Small Nuclear Ribonucleoprotein Complex
MRNA Methylguanosine-cap Decapping
Nuclear-transcribed MRNA Catabolic Process
U1 SnRNP
U5 SnRNP
RNA Decapping
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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