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SEPT4 and PARK2
Number of citations of the paper that reports this interaction (PMID
14559152
)
23
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
SEPT4
PARK2
Gene Name
septin 4
parkin RBR E3 ubiquitin protein ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Mitochondrion
Cytoskeleton
Sperm Annulus
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Aggresome
SCF Ubiquitin Ligase Complex
Neuron Projection
Perinuclear Region Of Cytoplasm
LUBAC Complex
Lewy Body
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
GTPase Activity
Structural Molecule Activity
Protein Binding
GTP Binding
G-protein Coupled Receptor Binding
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Tubulin Binding
Ligase Activity
SH3 Domain Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
Biological Process
Apoptotic Process
Cell Cycle
Brain Development
Metabolic Process
Sperm Mitochondrion Organization
Positive Regulation Of Protein Ubiquitination
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Sperm Capacitation
Cell Division
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Protein Polyubiquitination
Mitochondrial Fission
Mitochondrion Degradation
Negative Regulation Of Protein Phosphorylation
Startle Response
Transcription, DNA-templated
Protein Monoubiquitination
Response To Oxidative Stress
Mitochondrion Organization
Central Nervous System Development
Learning
Adult Locomotory Behavior
Regulation Of Autophagy
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Regulation Of Dopamine Secretion
Protein Ubiquitination
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Cellular Protein Catabolic Process
Protein K27-linked Ubiquitination
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Regulation Of Neurotransmitter Secretion
Protein Stabilization
Dopamine Uptake Involved In Synaptic Transmission
Protein Autoubiquitination
Zinc Ion Homeostasis
Negative Regulation Of Cell Death
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Cellular Response To Manganese Ion
Protein K6-linked Ubiquitination
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Response To Toxic Substance
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Neuron Death
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Regulation Of Mitochondrion Degradation
Negative Regulation Of Oxidative Stress-induced Cell Death
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Testicular germ cell tumor (
23666239
)
Aging (
22773346
)
Disc degeneration (lumbar) (
22993228
)
Metabolite levels (
19043545
)
Pancreatic cancer (
20686608
)
Protein-Protein Interactions
9 interactors:
AREL1
PARK2
SEPT5
SEPT8
SNCA
SNCAIP
SNCB
UBC
XIAP
77 interactors:
AIMP2
ARR3
ARRB2
ATXN3
BAG5
CASK
CASP1
CASP8
CDK5
CHPF
CRX
CSNK1A1
CUL1
DLG1
DLX2
DNM1L
DYT10
EPS15
FAM46C
FBP1
FBXO7
FBXW7
GPR37
GRIN2B
HEXDC
IKBKG
MEOX1
MEOX2
MFN1
NDUFA4L2
PAFAH1B2
PDCD2
PICK1
PRKACA
PSMA1
PSMA7
PSMC5
PSMD4
RAC1
RAD1
RAD23A
RANBP2
RBCK1
REL
RGS2
RGS3
SEPT4
SEPT5
SIM2
SNCA
SNCAIP
STUB1
SYT11
TCF4
TOMM40
TOMM70A
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2J1
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2V1
UCHL1
YWHAH
ZNF746
Entrez ID
5414
5071
HPRD ID
04738
03967
Ensembl ID
ENSG00000108387
ENSG00000185345
Uniprot IDs
O43236
O60260
Q5VVX4
PDB IDs
1IYF
2JMO
4BM9
4I1F
4I1H
Enriched GO Terms of Interacting Partners
?
Dopamine Metabolic Process
Catecholamine Metabolic Process
Regulation Of Neurotransmitter Secretion
Phenol-containing Compound Metabolic Process
Positive Regulation Of Protein Linear Polyubiquitination
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Cell Death
Regulation Of Synaptic Vesicle Transport
Regulation Of Synaptic Transmission
Regulation Of Apoptotic Process
Negative Regulation Of Catalytic Activity
Regulation Of Cell Death
Dopamine Transport
Neurotransmitter Uptake
Synaptic Transmission, Dopaminergic
Positive Regulation Of Protein Ubiquitination
Regulation Of Neurotransmitter Levels
Regulation Of Dopamine Secretion
Neurotransmitter Transport
Negative Regulation Of Neuron Apoptotic Process
Protein Ubiquitination
Monoamine Transport
Synaptic Transmission
Cellular Response To Catecholamine Stimulus
Protein Modification By Small Protein Conjugation
Regulation Of Protein Ubiquitination
Negative Regulation Of Neuron Death
Regulation Of Secretion
Regulation Of Proteolysis
Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Death
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Protein Metabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Modification Process
Cell-cell Signaling
Neuron-neuron Synaptic Transmission
Regulation Of Signaling
Apoptotic Process
Regulation Of Vesicle-mediated Transport
Ammonium Transport
Programmed Cell Death
Regulation Of Cellular Localization
Negative Regulation Of Thrombin Receptor Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Regulation Of Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Protein Ubiquitination
Protein Polyubiquitination
Positive Regulation Of Protein Ubiquitination
Cellular Macromolecule Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Cellular Metabolic Process
Regulation Of Signaling
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Catabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Signaling
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Transferase Activity
Cell Death
Death
Positive Regulation Of Transferase Activity
Negative Regulation Of Signal Transduction
Regulation Of Proteolysis
Proteolysis
Positive Regulation Of Protein Modification Process
Regulation Of Cell Death
Positive Regulation Of Proteolysis
Negative Regulation Of Protein Ubiquitination
Apoptotic Process
Regulation Of Metabolic Process
Programmed Cell Death
Positive Regulation Of Signal Transduction
Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Regulation Of Catalytic Activity
Negative Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Tagcloud
?
ataxin
atp13a2
atxn3
b12
cag
cgg
chediak
coexist
cytopathies
fmr1
fragile
gaucher
gba
glucocerebrosidase
hereditary
higashi
idiopathic
joseph
kufor
levodopa
lyst
machado
parkin
parkinsonism
pn
polg1
premutation
rakeb
tremor
Tagcloud (Difference)
?
ataxin
atp13a2
atxn3
b12
cag
cgg
chediak
coexist
cytopathies
fmr1
fragile
gaucher
gba
glucocerebrosidase
hereditary
higashi
idiopathic
joseph
kufor
levodopa
lyst
machado
parkin
parkinsonism
pn
polg1
premutation
rakeb
tremor
Tagcloud (Intersection)
?