SEPT4 and AREL1

Number of citations of the paper that reports this interaction (PMID 23479728)
0

Data Source:
BioGRID (enzymatic study)

		SEPT4	AREL1
Gene Name		septin 4	apoptosis resistant E3 ubiquitin protein ligase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytoskeleton Sperm Annulus	Nucleus Cytoplasm Cytosol
	Molecular Function	GTPase Activity Structural Molecule Activity Protein Binding GTP Binding	Ubiquitin-protein Transferase Activity Ligase Activity
	Biological Process	Apoptotic Process Cell Cycle Brain Development Metabolic Process Sperm Mitochondrion Organization Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Sperm Capacitation Cell Division Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		9 interactors: AREL1 PARK2 SEPT5 SEPT8 SNCA SNCAIP SNCB UBC XIAP	4 interactors: DIABLO HTRA2 SEPT4 UBE2D1
Entrez ID		5414	9870
HPRD ID		04738	13794
Ensembl ID		ENSG00000108387	ENSG00000119682
Uniprot IDs		O43236	O15033
PDB IDs
Enriched GO Terms of Interacting Partners?		Dopamine Metabolic Process Catecholamine Metabolic Process Regulation Of Neurotransmitter Secretion Phenol-containing Compound Metabolic Process Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cell Death Regulation Of Synaptic Vesicle Transport Regulation Of Synaptic Transmission Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Cell Death Dopamine Transport Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Positive Regulation Of Protein Ubiquitination Regulation Of Neurotransmitter Levels Regulation Of Dopamine Secretion Neurotransmitter Transport Negative Regulation Of Neuron Apoptotic Process Protein Ubiquitination Monoamine Transport Synaptic Transmission Cellular Response To Catecholamine Stimulus Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Negative Regulation Of Neuron Death Regulation Of Secretion Regulation Of Proteolysis Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Cell-cell Signaling Neuron-neuron Synaptic Transmission Regulation Of Signaling Apoptotic Process Regulation Of Vesicle-mediated Transport Ammonium Transport Programmed Cell Death Regulation Of Cellular Localization Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Pentacyclic Triterpenoid Metabolic Process Positive Regulation Of Endopeptidase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Peptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Sperm Mitochondrion Organization Cell Death Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Oxidative Stress Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Protein Processing Regulation Of Apoptotic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Herbicide Regulation Of Endopeptidase Activity Mitochondrion Organization Protein Autoprocessing Regulation Of Mitochondrion Degradation Regulation Of Peptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Response To Oxidative Stress Negative Regulation Of Cell Cycle Cellular Response To Interferon-beta Sperm Capacitation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Interferon-beta Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
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