SEPT4 and SNCAIP

Number of citations of the paper that reports this interaction (PMID 12695511)
21

Data Source:
HPRD (in vivo)

		SEPT4	SNCAIP
Gene Name		septin 4	synuclein, alpha interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytoskeleton Sperm Annulus	Cytoplasm Synaptic Vesicle Presynaptic Membrane Neuronal Cell Body
	Molecular Function	GTPase Activity Structural Molecule Activity Protein Binding GTP Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Apoptotic Process Cell Cycle Brain Development Metabolic Process Sperm Mitochondrion Organization Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Sperm Capacitation Cell Division Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly
Pathways
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		9 interactors: AREL1 PARK2 SEPT5 SEPT8 SNCA SNCAIP SNCB UBC XIAP	19 interactors: AES AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PARK2 PINK1 PPHLN1 PPP1CA PTN RNF19A SEPT4 SH2D3C SIAH1 SIAH2 SNCA UBB
Entrez ID		5414	9627
HPRD ID		04738	04804
Ensembl ID		ENSG00000108387	ENSG00000064692
Uniprot IDs		O43236	Q9NVG1 Q9Y6H5
PDB IDs			2KES
Enriched GO Terms of Interacting Partners?		Dopamine Metabolic Process Catecholamine Metabolic Process Regulation Of Neurotransmitter Secretion Phenol-containing Compound Metabolic Process Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cell Death Regulation Of Synaptic Vesicle Transport Regulation Of Synaptic Transmission Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Cell Death Dopamine Transport Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Positive Regulation Of Protein Ubiquitination Regulation Of Neurotransmitter Levels Regulation Of Dopamine Secretion Neurotransmitter Transport Negative Regulation Of Neuron Apoptotic Process Protein Ubiquitination Monoamine Transport Synaptic Transmission Cellular Response To Catecholamine Stimulus Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Negative Regulation Of Neuron Death Regulation Of Secretion Regulation Of Proteolysis Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Cell-cell Signaling Neuron-neuron Synaptic Transmission Regulation Of Signaling Apoptotic Process Regulation Of Vesicle-mediated Transport Ammonium Transport Programmed Cell Death Regulation Of Cellular Localization Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process	Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Proteolysis Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Protein Ubiquitination Regulation Of Proteolysis Regulation Of Dopamine Secretion Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Dopamine Uptake Involved In Synaptic Transmission Modification-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Synaptic Vesicle Transport Regulation Of Signaling Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitochondrion Organization Positive Regulation Of Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Glycogen Metabolic Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process
Tagcloud ?			adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 ranbp2 respective rps6kl1 sequenced spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Difference) ?			adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 ranbp2 respective rps6kl1 sequenced spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Intersection) ?