SEPT4 and SEPT8

Number of citations of the paper that reports this interaction (PMID 15116257)
4

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SEPT4	SEPT8
Gene Name		septin 4	septin 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytoskeleton Sperm Annulus	Cytoplasm Cytoskeleton
	Molecular Function	GTPase Activity Structural Molecule Activity Protein Binding GTP Binding	Protein Binding GTP Binding
	Biological Process	Apoptotic Process Cell Cycle Brain Development Metabolic Process Sperm Mitochondrion Organization Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Sperm Capacitation Cell Division Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Cycle
Pathways
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		9 interactors: AREL1 PARK2 SEPT5 SEPT8 SNCA SNCAIP SNCB UBC XIAP	9 interactors: A2M CDK14 JADE1 KMT2B PPHLN1 SEPT4 SEPT5 SH3GL1 SH3GL3
Entrez ID		5414	23176
HPRD ID		04738	12228
Ensembl ID		ENSG00000108387	ENSG00000164402
Uniprot IDs		O43236	A6NFQ9 B7ZVZ1 F6W7K9 Q92599
PDB IDs
Enriched GO Terms of Interacting Partners?		Dopamine Metabolic Process Catecholamine Metabolic Process Regulation Of Neurotransmitter Secretion Phenol-containing Compound Metabolic Process Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cell Death Regulation Of Synaptic Vesicle Transport Regulation Of Synaptic Transmission Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Cell Death Dopamine Transport Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Positive Regulation Of Protein Ubiquitination Regulation Of Neurotransmitter Levels Regulation Of Dopamine Secretion Neurotransmitter Transport Negative Regulation Of Neuron Apoptotic Process Protein Ubiquitination Monoamine Transport Synaptic Transmission Cellular Response To Catecholamine Stimulus Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Negative Regulation Of Neuron Death Regulation Of Secretion Regulation Of Proteolysis Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Cell-cell Signaling Neuron-neuron Synaptic Transmission Regulation Of Signaling Apoptotic Process Regulation Of Vesicle-mediated Transport Ammonium Transport Programmed Cell Death Regulation Of Cellular Localization Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process	Cell Division Sperm Mitochondrion Organization Negative Regulation Of Complement Activation, Lectin Pathway
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