MPHOSPH6 and ARHGAP18

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		MPHOSPH6	ARHGAP18
Description		M-phase phosphoprotein 6	Rho GTPase activating protein 18
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Ruffle Cytoplasm Cytosol Cytoplasmic Microtubule Plasma Membrane Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	GTPase Activator Activity Cadherin Binding
	Biological Process	Maturation Of 5.8S RRNA RRNA Processing	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Motility
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	RHOA GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Leukocyte telomere length ( 31171785 32109421) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Seasonality and depression ( 30217971)	Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Axial length ( 24144296) Cognitive function ( 24684796) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		28 interacting genes: AATF APLP1 ARHGAP18 CRYAA DNM2 DYNLRB1 EIF3G ERG28 EXOSC10 EXOSC3 EXOSC5 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1	2 interacting genes: MPHOSPH6 PALS2
Entrez ID		10200	93663
HPRD ID		16111	12474
Ensembl ID		ENSG00000135698	ENSG00000146376
Uniprot IDs		H3BNT4 Q99547	Q8N392
PDB IDs		6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?		Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) 3'-5'-RNA Exonuclease Activity Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity SnRNA Metabolic Process MRNA Metabolic Process RNA 3'-end Processing RNA Catabolic Process RNA Binding Nuclear-transcribed MRNA Catabolic Process SnRNA Catabolic Process Nuclear RNA Surveillance CUT Catabolic Process RNA Surveillance Regulation Of Female Gonad Development Regulation Of Telomere Maintenance Via Telomerase RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Catabolic Process U4 SnRNA 3'-end Processing Identical Protein Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus RRNA 3'-end Processing Euchromatin TRNA Decay Nuclear MRNA Surveillance Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Telomerase RNA Localization To Cajal Body MDM2/MDM4 Family Protein Binding DNA Deamination Negative Regulation Of Metabolic Process Nucleobase-containing Compound Catabolic Process Response To Heat Regulation Of DNA Biosynthetic Process RRNA Processing Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA Regulation Of Cell Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Apoptotic Process	Protein Insertion Into Mitochondrial Inner Membrane Mitochondrial Cytochrome C Oxidase Assembly NADH Dehydrogenase Complex Assembly Respiratory Chain Complex IV Assembly Respiratory Chain Complex III Mitochondrial Respiratory Chain Complex III Assembly Inner Mitochondrial Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Mitochondrial Respiratory Chain Complex I Assembly Cytochrome Complex Assembly Protein Insertion Into Mitochondrial Membrane Protein Insertion Into Mitochondrial Inner Membrane From Matrix Maturation Of 5.8S RRNA Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Organelle Protein Insertion Into Membrane Establishment Of Protein Localization To Mitochondrion Protein-containing Complex Assembly Mitochondrial Respiratory Chain Complex Assembly
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