MPHOSPH6 and THOP1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		MPHOSPH6	THOP1
Description		M-phase phosphoprotein 6	thimet oligopeptidase 1
Image
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Cytoplasm Mitochondrial Intermembrane Space Cytosol
	Molecular Function	RNA Binding Protein Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Maturation Of 5.8S RRNA RRNA Processing	Protein Polyubiquitination Proteolysis Peptide Metabolic Process
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Leukocyte telomere length ( 31171785 32109421) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Seasonality and depression ( 30217971)	Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 32888494) Plateletcrit ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		28 interacting genes: AATF APLP1 ARHGAP18 CRYAA DNM2 DYNLRB1 EIF3G ERG28 EXOSC10 EXOSC3 EXOSC5 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1	10 interacting genes: AGTR1 CALM1 EPN2 LINC01554 MPHOSPH6 PALS2 PRKACA STK11 TRAF2 TTC3
Entrez ID		10200	7064
HPRD ID		16111	03072
Ensembl ID		ENSG00000135698	ENSG00000172009
Uniprot IDs		H3BNT4 Q99547	P52888
PDB IDs		6D6Q 6D6R 6H25	1S4B 2O36
Enriched GO Terms of Interacting Partners?		Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) 3'-5'-RNA Exonuclease Activity Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity SnRNA Metabolic Process MRNA Metabolic Process RNA 3'-end Processing RNA Catabolic Process RNA Binding Nuclear-transcribed MRNA Catabolic Process SnRNA Catabolic Process Nuclear RNA Surveillance CUT Catabolic Process RNA Surveillance Regulation Of Female Gonad Development Regulation Of Telomere Maintenance Via Telomerase RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Catabolic Process U4 SnRNA 3'-end Processing Identical Protein Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus RRNA 3'-end Processing Euchromatin TRNA Decay Nuclear MRNA Surveillance Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Telomerase RNA Localization To Cajal Body MDM2/MDM4 Family Protein Binding DNA Deamination Negative Regulation Of Metabolic Process Nucleobase-containing Compound Catabolic Process Response To Heat Regulation Of DNA Biosynthetic Process RRNA Processing Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA Regulation Of Cell Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Apoptotic Process	Calcium-mediated Signaling Positive Regulation Of Cholesterol Metabolic Process Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Blood Circulation Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Sperm Midpiece Angiotensin Type I Receptor Activity Regulation Of Interleukin-2 Production TORC1 Signaling TORC2 Complex Disassembly Negative Regulation Of TORC1 Signaling Intracellular Signaling Cassette Bradykinin Receptor Binding Positive Regulation Of Signal Transduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction Negative Regulation Of TOR Signaling TOR Signaling TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Regulation Of Calcium-mediated Signaling Angiotensin Type II Receptor Activity Intracellular Signal Transduction Phospholipase C-activating Angiotensin-activated Signaling Pathway Renal System Process Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Steroid Metabolic Process Protein Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Heart Rate Regulation Of Striated Muscle Contraction Regulation Of TORC1 Signaling Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Intracellular Protein-containing Complex Positive Regulation Of Vesicle Transport Along Microtubule Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Multicellular Organismal Process Positive Regulation Of Lipid Metabolic Process Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?