MPHOSPH6 and PARN

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		MPHOSPH6	PARN
Gene Name		M-phase phosphoprotein 6	poly(A)-specific ribonuclease
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm	Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Maturation Of 5.8S RRNA	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Female Gamete Generation RNA Modification Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		24 interactors: AATF APLP1 ARHGAP18 C14orf1 DNM2 DYNLRB1 EIF3G EXOSC10 FTL GDF9 KNSTRN LRIF1 NUPR1 PARN RBM48 RPS20 SKIV2L2 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1	5 interactors: KHSRP MAPKAPK2 MPHOSPH6 MPP6 SPATC1L
Entrez ID		10200	5073
HPRD ID		16111	07250
Ensembl ID		ENSG00000135698	ENSG00000140694
Uniprot IDs		Q99547	B3KN69 B4DSB0 O95453
PDB IDs			2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Regulation Of Female Gonad Development Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Maturation Of 5.8S RRNA Positive Regulation Of Protein Oligomerization Ribonucleoprotein Complex Biogenesis Regulation Of Cell Growth Endocytosis Regulation Of Protein Oligomerization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic Cell Cycle Process Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of Cell Growth MRNA Catabolic Process Negative Regulation Of Fibroblast Proliferation Nitrogen Compound Metabolic Process Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Cell Division Regulation Of Gene Expression RNA Catabolic Process Ribosome Biogenesis Regulation Of Metabolic Process Mitotic Cytokinesis Negative Regulation Of Reactive Oxygen Species Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Clathrin-mediated Endocytosis Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Membrane Organization Growth Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Growth Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Processing Regulation Of Apoptotic Process Negative Regulation Of Macromitophagy Negative Regulation Of Membrane Tubulation Lipid Tube Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Negative Regulation Of Caveolin-mediated Endocytosis Oocyte Growth	Maturation Of 5.8S RRNA RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Macropinocytosis Ribonucleoprotein Complex Biogenesis Regulation Of MiRNA Metabolic Process 3'-UTR-mediated MRNA Stabilization
Tagcloud ?			ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr
Tagcloud (Difference) ?			ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr
Tagcloud (Intersection) ?