MPHOSPH6 and KNSTRN

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		MPHOSPH6	KNSTRN
Gene Name		M-phase phosphoprotein 6	kinetochore-localized astrin/SPAG5 binding protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Cytoplasm Microtubule Cytoskeleton Microtubule Plus-end Mitotic Spindle
	Molecular Function	RNA Binding Protein Binding	Protein Binding
	Biological Process	Maturation Of 5.8S RRNA	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		24 interactors: AATF APLP1 ARHGAP18 C14orf1 DNM2 DYNLRB1 EIF3G EXOSC10 FTL GDF9 KNSTRN LRIF1 NUPR1 PARN RBM48 RPS20 SKIV2L2 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1	7 interactors: CHMP1B CLU MAPK6 MPHOSPH6 MPP6 NUPR1 ZDHHC17
Entrez ID		10200	90417
HPRD ID		16111	12669
Ensembl ID		ENSG00000135698	ENSG00000128944
Uniprot IDs		Q99547	Q9Y448
PDB IDs
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Regulation Of Female Gonad Development Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Maturation Of 5.8S RRNA Positive Regulation Of Protein Oligomerization Ribonucleoprotein Complex Biogenesis Regulation Of Cell Growth Endocytosis Regulation Of Protein Oligomerization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic Cell Cycle Process Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of Cell Growth MRNA Catabolic Process Negative Regulation Of Fibroblast Proliferation Nitrogen Compound Metabolic Process Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Cell Division Regulation Of Gene Expression RNA Catabolic Process Ribosome Biogenesis Regulation Of Metabolic Process Mitotic Cytokinesis Negative Regulation Of Reactive Oxygen Species Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Clathrin-mediated Endocytosis Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Membrane Organization Growth Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Growth Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Processing Regulation Of Apoptotic Process Negative Regulation Of Macromitophagy Negative Regulation Of Membrane Tubulation Lipid Tube Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Negative Regulation Of Caveolin-mediated Endocytosis Oocyte Growth	Maturation Of 5.8S RRNA Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Positive Regulation Of Neurofibrillary Tangle Assembly RRNA Processing RRNA Metabolic Process Central Nervous System Myelin Maintenance Intrinsic Apoptotic Signaling Pathway Ribosome Biogenesis Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Positive Regulation Of Beta-amyloid Formation Regulation Of Mitotic Spindle Assembly Protein Complex Assembly Negative Regulation Of Protein Oligomerization Negative Regulation Of Beta-amyloid Formation Regulation Of Spindle Assembly Regulation Of Female Gonad Development Ribonucleoprotein Complex Biogenesis Regulation Of Protein Complex Assembly Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Regulation Of Mitotic Spindle Organization Negative Regulation Of Amyloid Precursor Protein Catabolic Process Apoptotic Signaling Pathway Glial Cell Proliferation Response To Misfolded Protein Regulation Of Beta-amyloid Formation Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Cell Separation After Cytokinesis Central Nervous System Myelination Lipoprotein Transport Protein Transport Magnesium Ion Transport Establishment Of Protein Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage NcRNA Metabolic Process Mitotic Metaphase Plate Congression Regulation Of Protein Oligomerization Protein Palmitoylation Macrophage Activation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Release Of Cytochrome C From Mitochondria Metaphase Plate Congression Myelin Maintenance
Tagcloud ?			aneuploidy carcinomas chromatid cohesion concentrated correlate cutaneous discovery disrupt encodes encoding enhance hotspot kinetochore mutagenesis mutations notably occur precursors recurrent report scc sccs ser24phe signature squamous tumorigenesis tumors ultraviolet
Tagcloud (Difference) ?			aneuploidy carcinomas chromatid cohesion concentrated correlate cutaneous discovery disrupt encodes encoding enhance hotspot kinetochore mutagenesis mutations notably occur precursors recurrent report scc sccs ser24phe signature squamous tumorigenesis tumors ultraviolet
Tagcloud (Intersection) ?