AGR2 and CRYGA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGR2	CRYGA
Description		anterior gradient 2, protein disulphide isomerase family member	crystallin gamma A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Structural Constituent Of Eye Lens
	Biological Process	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Eye Development Lens Development In Camera-type Eye Visual Perception
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1	5 interacting genes: AGR2 DPH2 HSPA13 PSMB9 TRAF1
Entrez ID		10551	1418
HPRD ID		05896	00433
Ensembl ID		ENSG00000106541	ENSG00000168582
Uniprot IDs		O95994 Q4JM46	A0A0S2A4T3 P11844
PDB IDs		2LNS 2LNT
Enriched GO Terms of Interacting Partners?		Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway	2-(3-amino-3-carboxypropyl)histidine Synthase Complex Protein Histidyl Modification To Diphthamide 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Threonine-type Endopeptidase Activity Spermatoproteasome Complex Proteasome Core Complex, Beta-subunit Complex Thioesterase Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Muscle Atrophy Ripoptosome Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Hepatocyte Apoptotic Process Skeletal Myofibril Assembly Negative Regulation Of Myoblast Fusion Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Death-inducing Signaling Complex Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Skeletal Muscle Atrophy CD95 Death-inducing Signaling Complex Skeletal Muscle Adaptation Regulation Of Glomerular Mesangial Cell Proliferation Striated Muscle Atrophy Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Glomerular Mesangial Cell Proliferation Lung Goblet Cell Differentiation Dystroglycan Binding Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Nitric Oxide Death Receptor Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Hepatocyte Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Reactive Nitrogen Species Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Mucus Secretion
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