AGR2 and DCAF11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGR2	DCAF11
Description		anterior gradient 2, protein disulphide isomerase family member	DDB1 and CUL4 associated factor 11
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum	Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Respiratory System Process Response To Oxidative Stress Memory Gene Expression Protein Ubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Cognition
Pathways			Neddylation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1	15 interacting genes: AGR2 CDKN1A CRYAA CUL4B DDB1 FKBP1A GPSM1 PTEN RCN1 SLBP TNNI1 TNNI2 TNS2 TRIM55 TRIM63
Entrez ID		10551	80344
HPRD ID		05896	18297
Ensembl ID		ENSG00000106541	ENSG00000100897
Uniprot IDs		O95994 Q4JM46	B3KSW2 Q59GN6 Q8TEB1
PDB IDs		2LNS 2LNT
Enriched GO Terms of Interacting Partners?		Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway	Response To UV Cul4B-RING E3 Ubiquitin Ligase Complex Troponin Complex Cellular Response To UV Cul4A-RING E3 Ubiquitin Ligase Complex UV-damage Excision Repair Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Cellular Response To Light Stimulus Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Meiotic Spindle Organization Protein Refolding Cul4-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Phosphate Metabolic Process Molecular Function Inhibitor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Radiation Skeletal Muscle Contraction Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Response To Electrical Stimulus Developmental Process Cardiac Muscle Contraction Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Mitotic Cell Cycle Macrolide Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Catabolic Process Regulation Of System Process Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cell Cycle G1/S Phase Transition PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of Growth Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Modification Process Damaged DNA Binding Protein Ubiquitination Cytoplasmic Side Of Membrane Regulation Of Muscle System Process Ryanodine Receptor Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity
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