AGR2 and CD34

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGR2	CD34
Description		anterior gradient 2, protein disulphide isomerase family member	CD34 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum	Extracellular Region Cytoplasm Lysosome Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Glomerular Endothelium Fenestra Intercellular Bridge Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Binding Carbohydrate Binding Sulfate Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Tissue Homeostasis Endothelial Cell Proliferation Glomerular Filtration Endothelium Development Cell Adhesion Cell-matrix Adhesion Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Negative Regulation Of Interleukin-2 Production Mesangial Cell-matrix Adhesion Paracrine Signaling Positive Regulation Of Odontogenesis Positive Regulation Of Angiogenesis Cell Motility Leukocyte Migration Transdifferentiation Vascular Wound Healing Hematopoietic Stem Cell Proliferation Positive Regulation Of Granulocyte Colony-stimulating Factor Production Extracellular Exosome Assembly Glomerular Endothelium Development Stem Cell Proliferation Metanephric Glomerular Mesangial Cell Differentiation Cell-cell Adhesion Positive Regulation Of Vasculogenesis
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Adventurousness ( 30643258) Age-related macular degeneration ( 23326517) Automobile speeding propensity ( 30643258) Drug experimentation measurement ( 30718321) Estimated glomerular filtration rate ( 31152163) Febrile seizures (MMR vaccine-related) ( 25344690) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Keratoconus ( 33649486) Refractive error ( 32231278) Resting heart rate ( 20639392 27798624) RR interval (heart rate) ( 30679814) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1	4 interacting genes: AGR2 CHST4 CRKL PRKCD
Entrez ID		10551	947
HPRD ID		05896	00790
Ensembl ID		ENSG00000106541	ENSG00000174059
Uniprot IDs		O95994 Q4JM46	P28906
PDB IDs		2LNS 2LNT
Enriched GO Terms of Interacting Partners?		Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway	Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cellular Localization Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Membrane Cell Chemotaxis Helper T Cell Diapedesis Chordate Pharynx Development Cerebellar Neuron Development Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Adhesion Negative Regulation Of Filopodium Assembly Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Phospholipid Scramblase Activity Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Endodeoxyribonuclease Activity Protein Kinase C Signaling Termination Of Signal Transduction Protein Sulfation Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Leukocyte Migration N-acetylglucosamine 6-O-sulfotransferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Diapedesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Parathyroid Gland Development Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Endodeoxyribonuclease Activity Regulation Of Phospholipid Catabolic Process Extrinsic Component Of Postsynaptic Membrane Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Defense Response Endolysosome Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Chemotaxis Cellular Response To Hydroperoxide Locomotion Positive Regulation Of Glial Cell Migration Immune Response-activating Signaling Pathway Postsynaptic Specialization Assembly
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