AGR2 and CETN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGR2	CETN3
Description		anterior gradient 2, protein disulphide isomerase family member	centrin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum	Nucleus Nuclear Envelope Nuclear Pore Nucleolus Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytoskeleton Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Basal Body Nuclear Pore Nuclear Basket Transcription Export Complex 2
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Calcium Ion Binding Protein Binding Microtubule Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Microtubule Cytoskeleton Organization Centrosome Cycle Protein Transport MRNA Transport Cell Division
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Rosacea symptom severity ( 29771307) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 19734900)
Interacting Genes		87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1	14 interacting genes: AGR2 CKMT2 HSPB1 IKBKG LDB2 LMNA LRIF1 LRRK2 MFHAS1 PDE6D RCN1 SGK1 TNNI1 UNC119
Entrez ID		10551	1070
HPRD ID		05896	04216
Ensembl ID		ENSG00000106541	ENSG00000153140
Uniprot IDs		O95994 Q4JM46	E5RFM2 E5RJF8 O15182
PDB IDs		2LNS 2LNT
Enriched GO Terms of Interacting Partners?		Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway	Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway System Process Protein Folding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Apoptotic Signaling Pathway Protein Folding Chaperone Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Protein Transport HSP90-CDC37 Chaperone Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Developmental Process DNA Double-strand Break Attachment To Nuclear Envelope Regulation Of System Process Structural Constituent Of Nuclear Lamina Visual Perception Sensory Perception Of Light Stimulus Regulation Of Catalytic Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Protein Localization To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Cellular Response To Stress Mitochondrion Response To Unfolded Protein Regulation Of Locomotion Protein Transport Response To Heat Regulation Of Protein Modification Process Protein Kinase C Inhibitor Activity Ubiquitin Protein Ligase Binding Linear Polyubiquitin Binding
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