AGR2 and BORCS8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGR2	BORCS8
Description		anterior gradient 2, protein disulphide isomerase family member	BLOC-1 related complex subunit 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum	Lysosome Lysosomal Membrane Membrane Cytoplasmic Side Of Lysosomal Membrane BORC Complex
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Heart Development Lysosome Localization Regulation Of Endosome Size Regulation Of Lysosome Size Organelle Transport Along Microtubule
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Height ( 28552196)
Interacting Genes		87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1	6 interacting genes: AGR2 CTAG1A CTAG1B MESD P2RX5 TEX11
Entrez ID		10551	729991
HPRD ID		05896	19682
Ensembl ID		ENSG00000106541	ENSG00000254901
Uniprot IDs		O95994 Q4JM46	Q96FH0
PDB IDs		2LNS 2LNT
Enriched GO Terms of Interacting Partners?		Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway	TRNA Threonylcarbamoyladenosine Metabolic Process Identical Protein Binding ATP-gated Ion Channel Activity Positive Regulation Of Protein Localization To Membrane Meiotic Gene Conversion Regulation Of Cellular Localization Osteoclast Maturation Gene Conversion Ligand-gated Monoatomic Anion Channel Activity Lung Goblet Cell Differentiation Male Meiosis Chromosome Segregation Regulation Of Protein Localization To Membrane Positive Regulation Of PERK-mediated Unfolded Protein Response TRNA Metabolic Process Regulation Of Skeletal Muscle Tissue Regeneration Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Central Element Chiasma Assembly Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Calcium Ion Import Across Plasma Membrane Dystroglycan Binding Voltage-gated Monoatomic Ion Channel Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Developmental Growth Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Receptor Clustering Meiotic Chromosome Segregation Mucus Secretion Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Receptor Clustering Resolution Of Meiotic Recombination Intermediates Ectopic Germ Cell Programmed Cell Death Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Calcium Ion Transport Into Cytosol Digestive Tract Morphogenesis Programmed Cell Death Involved In Cell Development Synaptonemal Complex Assembly
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