AGR2 and NDUFB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGR2	NDUFB2
Description		anterior gradient 2, protein disulphide isomerase family member	NADH:ubiquinone oxidoreductase subunit B2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways			Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1	6 interacting genes: AGR2 CDC7 LCN2 MEOX2 NDUFB7 PFKM
Entrez ID		10551	4708
HPRD ID		05896	11953
Ensembl ID		ENSG00000106541	ENSG00000090266
Uniprot IDs		O95994 Q4JM46	A4D1T5 O95178
PDB IDs		2LNS 2LNT	5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway	Positive Regulation Of Macromolecule Metabolic Process Response To Herbicide Positive Regulation Of Metabolic Process Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Siderophore Transport Cytoplasmic Vesicle Lumen Response To Mycotoxin Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Somite Specification ATP Metabolic Process Energy Derivation By Oxidation Of Organic Compounds 6-phosphofructokinase Activity Fructose-6-phosphate Binding Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate 6-phosphofructokinase Complex Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Endothelial Cell Migration Regulation Of Iron Ion Transport Response To Blue Light Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis Fructose Binding Positive Regulation Of Nuclear Cell Cycle DNA Replication Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of IRE1-mediated Unfolded Protein Response Cellular Response To X-ray Response To Fructose Dystroglycan Binding Purine Ribonucleotide Metabolic Process Short-term Memory Cellular Response To Increased Oxygen Levels Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Double-strand Break Repair Via Break-induced Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Generation Of Precursor Metabolites And Energy Fructose 6-phosphate Metabolic Process Cellular Response To Interleukin-6 Segment Specification Somite Development Positive Regulation Of DNA-templated DNA Replication
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