CCR1 and TMEFF1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		CCR1	TMEFF1
Name		C-C motif chemokine receptor 1	transmembrane protein with EGF like and two follistatin like domains 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Receptor Ligand Inhibitor Activity
	Biological Process	Dendritic Cell Chemotaxis Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Canonical NF-kappaB Signal Transduction Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response	Host-mediated Suppression Of Symbiont Invasion Symbiont Entry Into Host Cell
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	None
GWAS		Arthritis (juvenile idiopathic) ( 33106285 ) Aspartate aminotransferase levels ( 33547301 ) Behcet's disease ( 23291587 ) Celiac disease ( 18311140 20190752 22057235 30572963 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Heel bone mineral density ( 30598549 ) Inflammatory bowel disease ( 26192919 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Myocardial infarction ( 33532862 ) Narcolepsy with cataplexy ( 25986216 ) Ulcerative colitis ( 26192919 28067908 )	Aspartate aminotransferase levels ( 33547301 ) Familial squamous cell lung carcinoma ( 29924316 )
Novel Interactors		14 novel interactors: A4GNT CCL13 CDC25A CTNNB1 DAG1 DDX3Y DNAJB12 DUSP7 GNAI2 HAS3 KRT6A NPM1 PRSS50 PXMP2	None recorded
Interacting Genes		30 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 SNCA STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	10 interacting genes: APC BUB1 CCR1 CDKN2A DLC1 DYRK1A FLCN MLH3 PTEN PTPRJ
Entrez ID		1230	8577
HPRD ID		03101	04570
Ensembl ID		ENSG00000163823	ENSG00000241697
Uniprot IDs		P32246 Q5U003	Q8IYR6
PDB IDs		7VL8 7VL9 7VLA	Not available
GO Terms Enriched among Interactors		CCR Chemokine Receptor Binding Chemokine Activity Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Eosinophil Migration Antimicrobial Humoral Response Cytokine-mediated Signaling Pathway CCR1 Chemokine Receptor Binding Humoral Immune Response Chemotaxis Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Inflammatory Response Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cell Migration Response To External Biotic Stimulus Cell-cell Signaling Defense Response To Symbiont Regulation Of Cell Motility Monocyte Chemotaxis Defense Response Signaling Defense Response To Other Organism Response To Stress Cell Communication Response To Other Organism Calcium Ion Homeostasis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Calcium Ion Transport Immune Response Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Immune System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis	Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cellular Component Organization Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell-matrix Adhesion Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell-substrate Adhesion Regulation Of Cellular Component Organization Negative Regulation Of Kinase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Junction Assembly Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Junction Organization Regulation Of Focal Adhesion Assembly Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Regulation Of Protein Modification Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Gamma-catenin Binding Ruffle Membrane Beta-catenin Binding Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Negative Regulation Of Focal Adhesion Assembly Regulation Of Phosphorylation Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Catalytic Activity Cell Junction Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Migration