CCR1 and CCL3

Number of citations of the paper that reports this interaction (PubMedID 10202040)
0

Data Source:
HPRD (in vitro, in vivo)

		CCR1	CCL3
Description		C-C motif chemokine receptor 1	C-C motif chemokine ligand 3
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Cytosol
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding CCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Canonical NF-kappaB Signal Transduction Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Cell-cell Signaling Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Eosinophil Degranulation Positive Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Host-mediated Suppression Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Chemokine receptors bind chemokines Interleukin-10 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs			ROX-888
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Aspartate aminotransferase levels ( 33547301) Behcet's disease ( 23291587) Celiac disease ( 18311140 20190752 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Myocardial infarction ( 33532862) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971)
Interacting Genes		30 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 SNCA STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	12 interacting genes: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SNCA SRGN TGFB1 UBQLN1 UBQLN2
Entrez ID		1230	6348
HPRD ID		03101	01656
Ensembl ID		ENSG00000163823	ENSG00000277632
Uniprot IDs		P32246 Q5U003	A0N0R1 P10147
PDB IDs		7VL8 7VL9 7VLA	1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 4RA8 4ZKB 5COR 5D65 7F1Q 7F1T
Enriched GO Terms of Interacting Partners?		CCR Chemokine Receptor Binding Chemokine Activity Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Eosinophil Migration Antimicrobial Humoral Response Cytokine-mediated Signaling Pathway CCR1 Chemokine Receptor Binding Humoral Immune Response Chemotaxis Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Inflammatory Response Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cell Migration Response To External Biotic Stimulus Cell-cell Signaling Defense Response To Symbiont Regulation Of Cell Motility Monocyte Chemotaxis Defense Response Signaling Defense Response To Other Organism Response To Stress Cell Communication Response To Other Organism Calcium Ion Homeostasis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Calcium Ion Transport Immune Response Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Immune System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis	Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Inflammatory Response Cell Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Chemotaxis Calcium-mediated Signaling Locomotion Cytokine-mediated Signaling Pathway Response To Stress Regulation Of Calcium Ion Transport Immune Response Chemokine (C-C Motif) Ligand 5 Binding Immune System Process Negative Regulation Of Biomineral Tissue Development Defense Response Cell Migration Response To Cytokine Response To Peptide Regulation Of Metal Ion Transport Cell Motility External Side Of Plasma Membrane Negative Regulation Of Ossification G Protein-coupled Receptor Activity Positive Regulation Of Inflammatory Response Regulation Of Monoatomic Ion Transport Cellular Response To Cytokine Stimulus G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Transport Regulation Of Transport Dendritic Cell Chemotaxis Tolerance Induction Positive Regulation Of ERAD Pathway Negative Regulation Of Bone Mineralization Regulation Of Ossification Regulation Of Myeloid Leukocyte Differentiation Identical Protein Binding Regulation Of Sequestering Of Calcium Ion Leukocyte Chemotaxis Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Mononuclear Cell Migration Positive Regulation Of Chemotaxis Response To Cholesterol Regulation Of ERAD Pathway Regulation Of Calcium Ion Transmembrane Transport
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