CCR1 and CCL3L1

Number of citations of the paper that reports this interaction (PMID 11449371)
12

Data Source:
HPRD (in vitro, in vivo)

		CCR1	CCL3L1
Gene Name		chemokine (C-C motif) receptor 1	chemokine (C-C motif) ligand 3-like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Chemokine Activity
	Biological Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Metabolic Process Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis	Inflammatory Response Immune Response Negative Regulation Of Cell Proliferation Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140)
Protein-Protein Interactions		20 interactors: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CREB3 GNA14 JAK1 PLP2 STAT1 STAT3 TPST1 TPST2	4 interactors: CCR1 CCR3 CCR5 DPP4
Entrez ID		1230	6349
HPRD ID		03101	03234
Ensembl ID		ENSG00000163823	ENSG00000205021
Uniprot IDs		P32246 Q5U003	P16619
PDB IDs		1Y5D
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Chemotaxis Inflammatory Response Locomotion Cell Migration Cell Motility Immune Response Defense Response Response To External Stimulus Movement Of Cell Or Subcellular Component Monocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Cellular Calcium Ion Homeostasis Immune System Process Calcium Ion Homeostasis Positive Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Chemical Homeostasis Cellular Metal Ion Homeostasis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Chemotaxis Regulation Of Behavior Positive Regulation Of Cellular Component Movement Ion Homeostasis Positive Regulation Of Locomotion Cellular Response To Stimulus Positive Regulation Of Calcium Ion Transport Regulation Of Cell Migration Cell-cell Signaling Regulation Of Cell Motility Leukocyte Chemotaxis Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Eosinophil Chemotaxis Regulation Of Locomotion Homeostatic Process Regulation Of Cellular Component Movement Eosinophil Migration Cellular Homeostasis	Chemokine-mediated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Dendritic Cell Chemotaxis Dendritic Cell Migration Cellular Calcium Ion Homeostasis Locomotion Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Inflammatory Response Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Cellular Defense Response Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Cytokine Stimulus Chemotaxis Cellular Homeostasis Response To Cytokine Leukocyte Chemotaxis Cell Migration Chemical Homeostasis Cell Motility G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Response To Stress Cell Adhesion Leukocyte Migration Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Defense Response Homeostatic Process Movement Of Cell Or Subcellular Component Calcium Ion Transport Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cell-cell Adhesion Mediated By Integrin Response To External Stimulus Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Organic Substance Regulation Of Monocyte Chemotaxis Immune System Process Viral Process Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Response To Cholesterol Response To Organic Substance
Tagcloud ?		7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	cartilage ccl20 ccl4l2 ccl8 cxcl2 cxcl3 damps hmga hmgb hmgb1 hmgb2 hmgi hmgn hmgs immunohistological lef1 nfkappab1 nfkappab2 oa perpetuate s100a s100a11 spondins sry subchondral untangle
Tagcloud (Difference) ?		7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	cartilage ccl20 ccl4l2 ccl8 cxcl2 cxcl3 damps hmga hmgb hmgb1 hmgb2 hmgi hmgn hmgs immunohistological lef1 nfkappab1 nfkappab2 oa perpetuate s100a s100a11 spondins sry subchondral untangle
Tagcloud (Intersection) ?