CCR1 and LETMD1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR1	LETMD1
Description		C-C motif chemokine receptor 1	LETM1 domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Nucleoplasm Nucleolus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein Binding Ribosome Binding Molecular Adaptor Activity
	Biological Process	Dendritic Cell Chemotaxis Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Canonical NF-kappaB Signal Transduction Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response	ATP Biosynthetic Process Phagocytosis Inflammatory Response Mitochondrion Organization Gene Expression Response To Lipopolysaccharide Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Inflammatory Response Regulation Of Phagocytosis Mitochondrial Calcium Ion Homeostasis Positive Regulation Of Cold-induced Thermogenesis Reactive Oxygen Species Biosynthetic Process
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Aspartate aminotransferase levels ( 33547301) Behcet's disease ( 23291587) Celiac disease ( 18311140 20190752 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Myocardial infarction ( 33532862) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		30 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 SNCA STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	11 interacting genes: APOC1 APOC2 APOC4 APP CCR1 FBXO7 HCK RHBDD2 SH2D1A TMEM167B UBC
Entrez ID		1230	25875
HPRD ID		03101	09978
Ensembl ID		ENSG00000163823	ENSG00000050426
Uniprot IDs		P32246 Q5U003	A0A384P5D7 F8VP71 F8W1Z2 Q6P1Q0
PDB IDs		7VL8 7VL9 7VLA
Enriched GO Terms of Interacting Partners?		CCR Chemokine Receptor Binding Chemokine Activity Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Eosinophil Migration Antimicrobial Humoral Response Cytokine-mediated Signaling Pathway CCR1 Chemokine Receptor Binding Humoral Immune Response Chemotaxis Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Inflammatory Response Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cell Migration Response To External Biotic Stimulus Cell-cell Signaling Defense Response To Symbiont Regulation Of Cell Motility Monocyte Chemotaxis Defense Response Signaling Defense Response To Other Organism Response To Stress Cell Communication Response To Other Organism Calcium Ion Homeostasis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Calcium Ion Transport Immune Response Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Immune System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis	High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Acylglycerol Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Triglyceride Homeostasis Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Chylomicron Phospholipid Efflux Regulation Of Endocytosis Low-density Lipoprotein Particle Negative Regulation Of Lipoprotein Particle Clearance Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cholesterol Transport Positive Regulation Of Monocyte Chemotaxis Chemical Homeostasis Molecular Function Activator Activity Plasma Lipoprotein Particle Clearance Lipid Homeostasis Positive Regulation Of Defense Response Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Monocyte Chemotaxis Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Exocytosis Regulation Of Vesicle-mediated Transport Regulation Of Triglyceride Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Lipid Catabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein Metabolic Process Homeostatic Process Regulation Of Cholesterol Transport
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