CCR1 and GNA14

Number of citations of the paper that reports this interaction (PubMedID 8626727)
0

Data Source:
HPRD (in vitro, in vivo)

		CCR1	GNA14
Description		C-C motif chemokine receptor 1	G protein subunit alpha 14
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Extracellular Exosome
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Dendritic Cell Chemotaxis Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Canonical NF-kappaB Signal Transduction Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response	Action Potential Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Aspartate aminotransferase levels ( 33547301) Behcet's disease ( 23291587) Celiac disease ( 18311140 20190752 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Myocardial infarction ( 33532862) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder ( 31043756) Delirium ( 29631748) Thoracic aortic calcification levels ( 31659325)
Interacting Genes		30 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 SNCA STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	9 interacting genes: ADRB2 CCR1 CHRM2 CXCR1 CXCR2 DNAL4 JMJD6 OPRL1 SSTR2
Entrez ID		1230	9630
HPRD ID		03101	05095
Ensembl ID		ENSG00000163823	ENSG00000156049
Uniprot IDs		P32246 Q5U003	O95837
PDB IDs		7VL8 7VL9 7VLA
Enriched GO Terms of Interacting Partners?		CCR Chemokine Receptor Binding Chemokine Activity Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Eosinophil Migration Antimicrobial Humoral Response Cytokine-mediated Signaling Pathway CCR1 Chemokine Receptor Binding Humoral Immune Response Chemotaxis Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Inflammatory Response Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cell Migration Response To External Biotic Stimulus Cell-cell Signaling Defense Response To Symbiont Regulation Of Cell Motility Monocyte Chemotaxis Defense Response Signaling Defense Response To Other Organism Response To Stress Cell Communication Response To Other Organism Calcium Ion Homeostasis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Calcium Ion Transport Immune Response Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Immune System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Dendritic Cell Chemotaxis Chemokine Receptor Activity Dendritic Cell Migration C-C Chemokine Binding C-C Chemokine Receptor Activity Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Interleukin-8 Binding Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane C-X-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mononuclear Cell Migration Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Binding Receptor-mediated Endocytosis Signal Transduction Vesicle-mediated Transport Cell Chemotaxis Import Into Cell Leukocyte Migration Neutrophil Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential Chemotaxis Neutrophil Migration Nociceptin Receptor Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Intracellular Signaling Cassette External Side Of Plasma Membrane Locomotion Granulocyte Chemotaxis Regulation Of Bone Mineralization Beta2-adrenergic Receptor Activity
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