PLG and S100A10

Number of citations of the paper that reports this interaction (PMID 11939791)
5

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		PLG	S100A10
Gene Name		plasminogen	S100 calcium binding protein A10
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extrinsic Component Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding	Calcium Ion Binding Protein Binding Lipid Binding Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Membrane Raft Assembly Membrane Budding Positive Regulation Of Rac GTPase Activity Positive Regulation Of Binding Protein Heterotetramerization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters	Dissolution of Fibrin Clot Orphan transporters
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin
Diseases
GWAS		Aging ( 22773346) Lp (a) levels ( 21900290)
Protein-Protein Interactions		61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1	13 interactors: ANXA2 ANXA7 BAD CDK16 COPS6 CTSB FSHR KCNK3 PLA2G4C PLG SETDB1 TRPV5 TRPV6
Entrez ID		5340	6281
HPRD ID		01417	00232
Ensembl ID		ENSG00000122194	ENSG00000197747
Uniprot IDs		P00747 Q5TEH5	P60903
PDB IDs		1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG	1A4P 1BT6 4DRW 4FTG 4HRE 4HRG 4HRH
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity	Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Cellular Homeostasis Reproductive Process Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Calcium Ion Homeostasis Homeostatic Process Calcium Ion Homeostasis Cellular Response To Chromate Response To Metal Ion Extracellular Matrix Organization Extracellular Structure Organization Chemical Homeostasis Regulation Of Blood Coagulation Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Extracellular Matrix Disassembly Cellular Metal Ion Homeostasis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Anatomical Structure Development Protein Tetramerization Cellular Cation Homeostasis Mononuclear Cell Migration Cellular Response To Oxygen Levels Cellular Ion Homeostasis Response To Calcium Ion Catabolic Process Metal Ion Homeostasis Regulation Of Wound Healing Response To Inorganic Substance Reproductive Structure Development Reproductive System Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Apoptotic Process By Virus Glucose Catabolic Process Positive Regulation Of Fibrinolysis Cellular Response To Inorganic Substance Positive Regulation Of Type B Pancreatic Cell Development Follicle-stimulating Hormone Signaling Pathway Cellular Chemical Homeostasis Single Organism Reproductive Process Establishment Of Localization In Cell Organ Development System Development Developmental Process Ion Homeostasis Positive Regulation Of Glucokinase Activity
Tagcloud ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	annexin authentic baculovirus biochemical contained cytoskeleton derivatives display endocytic ii incorporation interference intestine lies mediating member mutants p11 porcine purified residue residues secretory ser serine spatial subjected substitutions
Tagcloud (Difference) ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	annexin authentic baculovirus biochemical contained cytoskeleton derivatives display endocytic ii incorporation interference intestine lies mediating member mutants p11 porcine purified residue residues secretory ser serine spatial subjected substitutions
Tagcloud (Intersection) ?