PLG and LAMA3

Number of citations of the paper that reports this interaction (PMID 10956663)
8

Data Source:
HPRD (in vitro)

		PLG	LAMA3
Gene Name		plasminogen	laminin, alpha 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-5 Complex Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding	Receptor Binding Structural Molecule Activity
	Biological Process	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Hemidesmosome Assembly Cell Junction Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development
Pathways		Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters	Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions ECM proteoglycans Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin
Diseases
GWAS		Aging ( 22773346) Lp (a) levels ( 21900290)	Amyotrophic lateral sclerosis ( 22959728)
Protein-Protein Interactions		61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1	7 interactors: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1
Entrez ID		5340	3909
HPRD ID		01417	02883
Ensembl ID		ENSG00000122194	ENSG00000053747
Uniprot IDs		P00747 Q5TEH5	B0YJ33 Q16787
PDB IDs		1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Muscle Cell Cellular Homeostasis Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Locomotion Regulation Of Blood Coagulation Movement Of Cell Or Subcellular Component Proteolysis Wound Healing Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Wound Healing Response To Wounding Tissue Development Positive Regulation Of Ovulation Mononuclear Cell Migration Cell Differentiation Response To Purine-containing Compound Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Odontogenesis Positive Regulation Of Fibrinolysis Cell Migration Cell Junction Assembly Cell Motility Metaphase/anaphase Transition Of Mitotic Cell Cycle Plasminogen Activation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Epidermis Development Anatomical Structure Morphogenesis Negative Regulation Of Fibrinolysis Response To Hypoxia Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Hemidesmosome Assembly Positive Regulation Of Pseudopodium Assembly Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Multicellular Organismal Development Negative Regulation Of Protein Processing Anatomical Structure Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Protein Processing Trophoblast Giant Cell Differentiation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Blood Coagulation Hemostasis Response To Caffeine
Tagcloud ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm sult2a1 tff top2a
Tagcloud (Difference) ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm sult2a1 tff top2a
Tagcloud (Intersection) ?