PLG and ENO1

Number of citations of the paper that reports this interaction (PMID 11169399)
8

Data Source:
HPRD (in vivo, in vitro)

		PLG	ENO1
Gene Name		plasminogen	enolase 1, (alpha)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Membrane M Band Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding	Magnesium Ion Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Phosphopyruvate Hydratase Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Negative Regulation Of Transcription From RNA Polymerase II Promoter Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Transcription, DNA-templated Pathogenesis Response To Virus Negative Regulation Of Cell Growth Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated
Pathways		Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin
Diseases
GWAS		Aging ( 22773346) Lp (a) levels ( 21900290)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1	20 interactors: AGTPBP1 AMBP BHLHE40 BRCA1 FANCA FYN GRB2 HDAC1 LIG4 MYOC PCNA PLG SERPING1 SRC SUMO4 TERT TRAPPC2 UPF2 YWHAQ YWHAZ
Entrez ID		5340	2023
HPRD ID		01417	01400
Ensembl ID		ENSG00000122194	ENSG00000074800
Uniprot IDs		P00747 Q5TEH5	E2DRY6 P06733
PDB IDs		1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG	2PSN 3B97
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity	Platelet Activation Blood Coagulation Hemostasis Developmental Process Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Organelle Organization Organ Development Cell Activation Response To Wounding Negative Regulation Of Signal Transduction Multicellular Organismal Development DNA Strand Elongation Negative Regulation Of Signaling Anatomical Structure Development System Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death ERBB Signaling Pathway Vesicle-mediated Transport Negative Regulation Of Cell-substrate Adhesion Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Stress Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Signaling DNA Replication Regulation Of Organelle Organization Nucleotide-excision Repair, DNA Gap Filling Regulation Of Mitochondrial Depolarization DNA Biosynthetic Process Cellular Metabolic Process Regulation Of Cell Proliferation Regulation Of Cell Adhesion Postreplication Repair Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Tagcloud ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	assigned carrying cell cells chromosome chromosomes electrophoresis enolase equilibrium expression gel gene human hybrids indicated mouse p36 pter reciprocal region results somatic starch tested translocation
Tagcloud (Difference) ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	assigned carrying cell cells chromosome chromosomes electrophoresis enolase equilibrium expression gel gene human hybrids indicated mouse p36 pter reciprocal region results somatic starch tested translocation
Tagcloud (Intersection) ?