PLG and PAPPA

Number of citations of the paper that reports this interaction (PMID 7586586)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		PLG	PAPPA
Gene Name		plasminogen	pregnancy-associated plasma protein A, pappalysin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Membrane
	Molecular Function	Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding	Metalloendopeptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Proteolysis Female Pregnancy Cell Differentiation Cellular Protein Metabolic Process
Pathways		Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin
Diseases
GWAS		Aging ( 22773346) Lp (a) levels ( 21900290)	Height ( 20881960 18391950)
Protein-Protein Interactions		61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1	10 interactors: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3
Entrez ID		5340	5069
HPRD ID		01417	01448
Ensembl ID		ENSG00000122194	ENSG00000182752
Uniprot IDs		P00747 Q5TEH5	Q13219 Q7Z613 Q86YM8 Q8IWT8
PDB IDs		1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Nodal Signaling Pathway Embryonic Foregut Morphogenesis Tissue Development Foregut Morphogenesis Paraxial Mesoderm Development Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA In Utero Embryonic Development Transcription Initiation From RNA Polymerase II Promoter Pericardium Development Regulation Of Cellular Component Organization Regulation Of Cellular Response To Growth Factor Stimulus Skeletal System Development Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Lens Fiber Cell Differentiation Response To Growth Factor Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Gene Silencing By MiRNA DNA-templated Transcription, Initiation Cellular Response To DsRNA Posttranscriptional Gene Silencing Developmental Growth SMAD Protein Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stem Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Kidney Development
Tagcloud ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	alleviate altering alternating american capillaries ccl2 closer coat concave convex dawley diepoxide endometrium eosin follicles ginseng glands hematoxylin nell1 ovarian pla2g4a pof premature sprague stc2 uterine vcd vinylcyclohexene visible
Tagcloud (Difference) ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	alleviate altering alternating american capillaries ccl2 closer coat concave convex dawley diepoxide endometrium eosin follicles ginseng glands hematoxylin nell1 ovarian pla2g4a pof premature sprague stc2 uterine vcd vinylcyclohexene visible
Tagcloud (Intersection) ?