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PLG
Gene Name
plasminogen
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Cell Surface
Platelet Alpha Granule Lumen
Extrinsic Component Of External Side Of Plasma Membrane
Extracellular Vesicular Exosome
Blood Microparticle
Molecular Function
Serine-type Endopeptidase Activity
Receptor Binding
Protein Binding
Serine-type Peptidase Activity
Protein Domain Specific Binding
Apolipoprotein Binding
Biological Process
Platelet Degranulation
Blood Coagulation
Negative Regulation Of Cell Proliferation
Negative Regulation Of Cell-substrate Adhesion
Extracellular Matrix Disassembly
Platelet Activation
Extracellular Matrix Organization
Tissue Regeneration
Fibrinolysis
Cellular Protein Metabolic Process
Myoblast Differentiation
Muscle Cell Cellular Homeostasis
Tissue Remodeling
Proteolysis Involved In Cellular Protein Catabolic Process
Negative Regulation Of Fibrinolysis
Positive Regulation Of Fibrinolysis
Transmembrane Transport
Trophoblast Giant Cell Differentiation
Labyrinthine Layer Blood Vessel Development
Mononuclear Cell Migration
Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways
Signaling by PDGF
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activation of Matrix Metalloproteinases
Dissolution of Fibrin Clot
Platelet degranulation
Degradation of the extracellular matrix
Response to elevated platelet cytosolic Ca2+
Platelet activation, signaling and aggregation
Orphan transporters
Drugs
Alteplase
Urokinase
Reteplase
Anistreplase
Tenecteplase
Streptokinase
Tranexamic Acid
Aminocaproic Acid
Bicine
Aprotinin
Diseases
GWAS
Aging (
22773346
)
Lp (a) levels (
21900290
)
Protein-protein Interactions
61 interactors:
ACTB
AMOT
ANXA2
APOH
ATP5B
C7
CDCP1
CHGA
CLEC3B
CP
CPB2
CXCL2
CYFIP2
ENO1
EP300
F10
F2R
F2RL1
F3
FN1
HMGB1
HRG
HSPA1A
HSPB1
HSPD1
IGF2
IGFBP3
KLK3
KNG1
LAMA1
LAMA3
LAMA5
MAPK14
MEP1A
MMP3
MMP7
MMP9
NGF
PAPPA
PCOLCE
PLAT
PLAU
PRDX4
PRNP
RAP2A
RBBP6
RUVBL1
S100A10
SERPINB13
SERPINB6
SERPINC1
SERPINE1
SERPINF2
SERPING1
SERPINI1
SMAD3
SMAD4
SPARC
TFPI2
THBS1
YTHDC1
Entrez ID
5340
HPRD ID
01417
Ensembl ID
ENSG00000122194
Uniprot IDs
P00747
Q5TEH5
PDB IDs
1B2I
1BML
1BUI
1CEA
1CEB
1DDJ
1HPJ
1HPK
1I5K
1KI0
1KRN
1L4D
1L4Z
1PK4
1PKR
1PMK
1QRZ
1RJX
2DOH
2DOI
2KNF
2L0S
2PK4
3UIR
4A5T
4DCB
4DUR
4DUU
5HPG
Enriched GO Terms of Interacting Partners
?
Regulation Of Blood Coagulation
Regulation Of Wound Healing
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Wound Healing
Response To Wounding
Regulation Of Protein Metabolic Process
Negative Regulation Of Wound Healing
Regulation Of Peptidase Activity
Fibrinolysis
Negative Regulation Of Blood Coagulation
Negative Regulation Of Coagulation
Regulation Of Cell Migration
Regulation Of Endopeptidase Activity
Regulation Of Cell Motility
Regulation Of Cellular Protein Metabolic Process
Regulation Of Proteolysis
Regulation Of Locomotion
Regulation Of Cellular Component Movement
Response To Stress
Regulation Of Fibrinolysis
Platelet Activation
Regulation Of Protein Processing
Positive Regulation Of Blood Coagulation
Negative Regulation Of Fibrinolysis
Cell Activation
Positive Regulation Of Coagulation
Platelet Degranulation
Extracellular Matrix Organization
Extracellular Structure Organization
Negative Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Wound Healing
Regulation Of Cell Adhesion
Regulation Of Cell Proliferation
Response To External Stimulus
Negative Regulation Of Protein Processing
Negative Regulation Of Cellular Protein Metabolic Process
Response To Stimulus
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Defense Response
Negative Regulation Of Endopeptidase Activity
Positive Regulation Of Cellular Component Movement
Negative Regulation Of Proteolysis
Positive Regulation Of Locomotion
Negative Regulation Of Peptidase Activity
Zymogen Activation
Negative Regulation Of Hydrolase Activity
Tagcloud
?
1f
a2hs
allel
alleles
asia
borderline
city
comparatively
corresponds
deviating
dissimilarity
distance
east
ethnic
f13b
gc
geographic
jekaterinburg
krakow
moscow
olomouc
polymorphic
poznan
prague
presumably
regard
szeged
tf
typed