PLG and F3

Number of citations of the paper that reports this interaction (PMID 9490681)
7

Data Source:
HPRD (in vitro)

		PLG	F3
Gene Name		plasminogen	coagulation factor III (thromboplastin, tissue factor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Matrix Intrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding	Protease Binding Cytokine Receptor Activity Protein Binding Phospholipid Binding
	Biological Process	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Positive Regulation Of Endothelial Cell Proliferation Activation Of Plasma Proteins Involved In Acute Inflammatory Response Activation Of Blood Coagulation Via Clotting Cascade Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Blood Coagulation Blood Coagulation, Extrinsic Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling
Pathways		Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters	Extrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin	Coagulation factor VIIa 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2\'-HYDROXY-3\'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3\'-NITRO-BIPHENYL-3-YL]-ACETIC ACID
Diseases
GWAS		Aging ( 22773346) Lp (a) levels ( 21900290)	D-dimer levels ( 21502573) End-stage coagulation ( 23381943) Type 2 diabetes ( 22238593)
Protein-Protein Interactions		61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1	5 interactors: F10 F7 FANCB FLNA PLG
Entrez ID		5340	2152
HPRD ID		01417	00603
Ensembl ID		ENSG00000122194	ENSG00000117525
Uniprot IDs		P00747 Q5TEH5	P13726
PDB IDs		1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG	1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1NL8 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity	Blood Coagulation, Extrinsic Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Peptidyl-glutamic Acid Carboxylation Response To Wounding Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Response To Stress Platelet Degranulation Positive Regulation Of Protein Kinase B Signaling Regulation Of Blood Coagulation Regulation Of Protein Kinase B Signaling Regulation Of Wound Healing Positive Regulation Of Intracellular Signal Transduction Protein Activation Cascade Response To Vitamin K Mononuclear Cell Migration Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Platelet Activation Post-translational Protein Modification Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Cellular Component Movement Negative Regulation Of Fibrinolysis Positive Regulation Of Locomotion Proteolysis MRNA Transcription From RNA Polymerase II Promoter Regulation Of Fibrinolysis MRNA Transcription Blood Coagulation, Intrinsic Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Trophoblast Giant Cell Differentiation Secretion By Cell Actin Crosslink Formation Response To Stimulus Cytoplasmic Sequestering Of Protein Labyrinthine Layer Blood Vessel Development Muscle Cell Cellular Homeostasis
Tagcloud ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	ag ba construct csf defective efficiently equivalence g gcsfr granulocyte granulopoiesis kinetics neutropenia nonsaturating r retain saturating scn stat1 stat3 stat5 transactivation transfectants triangle truncated tyrosines up715 y704 y744
Tagcloud (Difference) ?		1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed	ag ba construct csf defective efficiently equivalence g gcsfr granulocyte granulopoiesis kinetics neutropenia nonsaturating r retain saturating scn stat1 stat3 stat5 transactivation transfectants triangle truncated tyrosines up715 y704 y744
Tagcloud (Intersection) ?