PLG and ATP5F1B

Number of citations of the paper that reports this interaction (PubMedID 10077593)
38

Data Source:
HPRD (in vitro)

		PLG	ATP5F1B
Description		plasminogen	ATP synthase F1 subunit beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface Membrane Proton-transporting Two-sector ATPase Complex Mitochondrial Membrane Mitochondrial Nucleoid Proton-transporting ATP Synthase Complex Extracellular Exosome Transmembrane Transporter Complex
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Enzyme Binding Kinase Binding Protein Domain Specific Binding Apolipoprotein Binding Protein-folding Chaperone Binding Protein Antigen Binding	Nucleotide Binding Protein Binding ATP Binding MHC Class I Protein Binding Angiostatin Binding Metal Ion Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Proteolysis Blood Coagulation Hemostasis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Protein Processing Extracellular Matrix Disassembly Tissue Regeneration Fibrinolysis Positive Regulation Of Blood Vessel Endothelial Cell Migration Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Biological Process Involved In Interaction With Symbiont Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Angiogenesis Osteoblast Differentiation Generation Of Precursor Metabolites And Energy Lipid Metabolic Process ATP Biosynthetic Process Monoatomic Ion Transport Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Blood Vessel Endothelial Cell Migration ATP Metabolic Process Regulation Of Intracellular PH Cellular Response To Interleukin-7 Proton Transmembrane Transport
Pathways		Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Dissolution of Fibrin Clot	Mitochondrial protein import Mitochondrial protein import Formation of ATP by chemiosmotic coupling Transcriptional activation of mitochondrial biogenesis Cristae formation Mitochondrial protein degradation
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic acid Aminocaproic acid Bicine Desmoteplase Aprotinin Copper Gabexate	Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE Phenethyl Isothiocyanate
Diseases		Inherited thrombophilia
GWAS		Aging ( 22773346) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Childhood ear infection ( 28928442 27182965) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) End stage renal disease x APOL1 genotype interaction ( 29885931) Giant cell arteritis ( 28041642) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lp (a) levels ( 21900290) Myocardial infarction ( 26343387) Plasma plasminogen levels ( 25208887) Platelet count ( 32888494) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		62 interacting genes: ACTB AMOT ANXA2 APOH ATP5F1B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSP90AA1 HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SNCA SPARC TFPI2 THBS1 YTHDC1	29 interacting genes: ANXA7 APOA1 ATP5F1C ATPAF1 ATPAF2 BYSL CDK4 CDKN1A DOP1B DSCAM EIF4ENIF1 FANCA GRB7 HMOX2 HUNK LCOR LNX2 OGT PIN1 PLG PSME3 RPP14 SMN1 SUMO4 TERT TK1 TRIM55 TRIM63 YWHAG
Entrez ID		5340	506
HPRD ID		01417	00044
Ensembl ID		ENSG00000122194	ENSG00000110955
Uniprot IDs		P00747 Q5TEH5	P06576 V9HW31
PDB IDs		1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4CIK 4DCB 4DUR 4DUU 5HPG 5UGD 5UGG 6D3X 6D3Y 6D3Z 6D40 6OG4 6OQJ 6OQK 6Q1U 6UZ4 6UZ5 7E50 7THS 7UAH 8F7U 8F7V 8UQ6 9AZK	8H9E 8H9I 8H9L 8H9P 8H9S 8H9T 8H9U 8H9V 8KI3
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Wound Healing Extracellular Matrix Regulation Of Response To Wounding Extracellular Exosome Regulation Of Plasminogen Activation Regulation Of Multicellular Organismal Process Regulation Of Body Fluid Levels Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Fibrinolysis Negative Regulation Of Hemostasis Blood Coagulation Negative Regulation Of Coagulation Coagulation Negative Regulation Of Fibrinolysis Hemostasis Regulation Of Protein Processing Regulation Of Biological Quality Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Protein Maturation Positive Regulation Of Wound Healing Regulation Of Cell Motility Regulation Of Fibrinolysis Protease Binding Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Platelet Alpha Granule Lumen Positive Regulation Of Locomotion Positive Regulation Of Multicellular Organismal Process Peptidase Inhibitor Activity Cell Surface Negative Regulation Of Plasminogen Activation Positive Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Regulation Of Cell Adhesion Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Development Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Negative Regulation Of Protein Processing	Mitochondrial Proton-transporting ATP Synthase Complex Assembly Proton-transporting ATP Synthase Complex Assembly
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