LMO7 and LRIG3

Number of citations of the paper that reports this interaction (PubMedID 30429017)
0

Data Source:
BioGRID (two hybrid)

		LMO7	LRIG3
Description		LIM domain 7	leucine rich repeats and immunoglobulin like domains 3
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nuclear Envelope Cytoplasm Mitochondrion Cytosol Focal Adhesion Cell Surface Apical Plasma Membrane	Extracellular Space Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process	Sensory Perception Of Sound Otolith Morphogenesis
Pathways		Neddylation Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age-related hearing impairment ( 34108613) Cutaneous melanoma or hair colour ( 32341527) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29449654 33627673) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Intraocular pressure ( 29617998 29785010 30054594 31959993) Mean corpuscular hemoglobin ( 32888494) Multiple system atrophy (pathologically confirmed) ( 27629089) Obsessive-compulsive disorder ( 30456828) Type 1 diabetes ( 21980299)	Blood protein levels ( 30072576) Heart failure ( 20445134) Hematocrit ( 29403010) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311)
Interacting Genes		15 interacting genes: ABCA1 ANXA1 CALM1 DAPK3 DSCR9 EMD LRIG3 MDM2 PKM RHOU SRPK2 SUMO2 TBK1 UBAC2 YWHAG	3 interacting genes: LIMCH1 LMO7 MTDH
Entrez ID		4008	121227
HPRD ID		05078	08317
Ensembl ID		ENSG00000136153	ENSG00000139263
Uniprot IDs		A0A0A0MTE2 E9PMT2 F8J2B5 F8WD26 Q8WWI1	C9K080 Q6UXM1
PDB IDs		2EAQ
Enriched GO Terms of Interacting Partners?		Vesicle Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Export From Nucleus SUMO Transferase Activity Regulation Of Signal Transduction Protein Metabolic Process Protein Modification Process Cellular Response To Hormone Stimulus Regulation Of Cell Shape Presynaptic Cytosol Regulation Of Intracellular Protein Transport Amyloid Fibril Formation Positive Regulation Of Translation Positive Regulation Of Gene Expression Intracellular Signal Transduction Regulation Of Translation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Signal Transduction Response To Nutrient Levels Sphingolipid Floppase Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Myosin II Filament Organization TMEM240-body Regulation Of Protein Localization Response To Formaldehyde Cellular Response To Vitamin B1 Peptidyl-serine Phosphorylation Positive Regulation Of Translational Initiation Regulation Of Establishment Of Protein Localization Protein Sumoylation Presynapse Spindle Response To Vitamin B3 Regulation Of Multicellular Organismal Process Regulation Of Transport Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Alpha-beta T Cell Differentiation Response To Hormone Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Cycle G1/S Phase Transition Cilium Regulation Of Cell Morphogenesis Regulation Of Cell Cycle Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Post-transcriptional Regulation Of Gene Expression	Myosin II Head/neck Binding
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