LMO7 and PKM

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LMO7	PKM
Gene Name		LIM domain 7	pyruvate kinase, muscle
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Focal Adhesion	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cilium Extracellular Matrix Vesicle Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding	Magnesium Ion Binding Pyruvate Kinase Activity Protein Binding ATP Binding MHC Class II Protein Complex Binding Potassium Ion Binding Poly(A) RNA Binding
	Biological Process	Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion	Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Programmed Cell Death Phosphorylation Small Molecule Metabolic Process
Pathways
Drugs			Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2\',3\':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
Diseases
GWAS		Type 1 diabetes ( 21980299)
Protein-Protein Interactions		8 interactors: ABCA1 CALM1 EMD MDM2 PKM UBAC2 YWHAG YWHAQ	35 interactors: ANXA7 APP ARAF CDK4 CDKN1A EGLN3 EXOSC5 GRB7 HERC1 HIF1A LMO7 LNX1 MDM2 MYOC NAGK NDRG1 NXT2 OLFM2 PAX8 PIN1 POLE2 RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 TERF1 TINF2 TK1 TRIM63 UCHL5 YWHAQ
Entrez ID		4008	5315
HPRD ID		05078	01529
Ensembl ID		ENSG00000136153	ENSG00000067225
Uniprot IDs		E9PLH4 J3KP06 Q8WWI1	B4DNK4 P14618
PDB IDs		2EAQ	1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Membrane Organization Regulation Of Cellular Localization Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Protein Export From Nucleus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Substantia Nigra Development Regulation Of Protein Localization Regulation Of Signaling Cellular Response To Organic Substance Neural Nucleus Development Protein Localization Positive Regulation Of Mitochondrion Organization Positive Regulation Of CAMP Biosynthetic Process Programmed Cell Death Positive Regulation Of CAMP Metabolic Process Cell Death Death Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To UV-C Cellular Response To Vitamin B1 Midbrain Development Regulation Of CAMP Biosynthetic Process Cellular Response To Light Stimulus Regulation Of Mitochondrion Organization Regulation Of CAMP Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Response To Organic Substance Cellular Protein Localization Cellular Response To Growth Factor Stimulus Response To Growth Factor Establishment Of Protein Localization Cellular Response To Radiation Glucose Metabolic Process Carbohydrate Catabolic Process Mitotic Cell Cycle Process Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Traversing Start Control Point Of Mitotic Cell Cycle Interleukin-1 Beta Secretion Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway	Response To Abiotic Stimulus Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stress Regulation Of Signaling Intestinal Epithelial Cell Maturation Cellular Response To Hypoxia Telomere Maintenance Via Telomere Lengthening Cellular Response To Decreased Oxygen Levels Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Neurotrophin Signaling Pathway Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Response To Organic Substance Response To Organic Cyclic Compound Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Proteolysis Regulation Of Cell Cycle Response To Hormone Response To Inorganic Substance Response To Steroid Hormone Nervous System Development Regulation Of Cellular Component Organization Cell Maturation Response To Hypoxia Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Phase Transition Skeletal Muscle Adaptation Negative Regulation Of Telomere Maintenance G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		bcrp c9orf3 cassette cdyl chemotherapeutics chemotherapies conferred ctrl devised dock ehbp1 farnesol farnesylation farnesyltransferase foxa2 functionalized ine1 isoprenoid mdr1 mrp1 mrs2 neb numbl oils oncoproteins pharmacogenomic sesquiterpene stab2 urgently	acutely amplitudes applications aspartate blockade ca1 changing channel clamp coapplication combinations consequence currents heterodimeric hippocampal inside mg2 nmda nr1a nr2a nr2b opening patch patches potentiated potentiation probability sensitivities voltage
Tagcloud (Difference) ?		bcrp c9orf3 cassette cdyl chemotherapeutics chemotherapies conferred ctrl devised dock ehbp1 farnesol farnesylation farnesyltransferase foxa2 functionalized ine1 isoprenoid mdr1 mrp1 mrs2 neb numbl oils oncoproteins pharmacogenomic sesquiterpene stab2 urgently	acutely amplitudes applications aspartate blockade ca1 changing channel clamp coapplication combinations consequence currents heterodimeric hippocampal inside mg2 nmda nr1a nr2a nr2b opening patch patches potentiated potentiation probability sensitivities voltage
Tagcloud (Intersection) ?