RCC1 and PTMA

Number of citations of the paper that reports this interaction (PubMedID 11310559)
0

Data Source:
HPRD (in vitro)

		RCC1	PTMA
Description		regulator of chromosome condensation 1	prothymosin alpha
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GO Annotations	Cellular Component	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Protein-containing Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Nucleosome Binding Nucleosomal DNA Binding Histone Binding Sulfate Binding Protein Heterodimerization Activity	Protein Binding Histone Binding DNA-binding Transcription Factor Binding Histone Chaperone Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Membrane Reassembly Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Viral Process Spindle Assembly Cell Division Regulation Of Mitotic Spindle Assembly	Chromatin Organization DNA-templated Transcription Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Rev-mediated nuclear export of HIV RNA Nuclear import of Rev protein Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917) Systolic blood pressure ( 30578418)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951) Lymphocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		50 interacting genes: ACTB APLP1 BAG6 CCT7 CDK1 CDK2AP2 CEBPA CHGB CHKA CSAD CSNK1A1 DDAH2 DYNC1I1 ERCC6 FAF1 FBXO7 FLAD1 GNB2 H2AC18 H2AC20 H2BC21 H3C1 HADHB HMGA1 HOXD8 KMT2B KPNA3 LRIF1 NGFR NTMT1 NUDT21 NUP98 OGT PDHB PKM PTMA RAN RANBP1 RANBP3 SDF4 SPRED1 SUMO2 TLE1 TRMT2A TUBB3 UNC119 USP4 WIZ XPO1 ZNF135	43 interacting genes: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 FNDC3B GSK3A H1-1 H2AC14 H2BC21 H2BC8 H3-4 H3C14 H4C1 H4C14 HDAC1 HDAC2 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP VIPR1 ZDHHC17
Entrez ID		1104	5757
HPRD ID		01559	01778
Ensembl ID		ENSG00000180198	ENSG00000187514
Uniprot IDs		A0A0S2Z3I4 A0A0S2Z404 P18754 Q5T081	P06454 Q53S24
PDB IDs		1A12 1I2M 5E1B 5E1D 5E1M 5E1O 5E2A 5E2B 5TBK 6DUB 8UX1	2L9I 2MNQ
Enriched GO Terms of Interacting Partners?		Chromatin Organization Nucleoplasm Nucleus Chromatin Remodeling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Structural Constituent Of Chromatin Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleosome Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Kinetochore Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Protein Export From Nucleus Ribosomal Large Subunit Export From Nucleus Chromosome Positive Regulation Of DNA Metabolic Process Ribosomal Small Subunit Export From Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of DNA Replication Cytosol Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Nuclear Envelope Ribosomal Subunit Export From Nucleus Extracellular Exosome Nuclear Export Nuclear Export Signal Receptor Activity Protein Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Biosynthetic Process Nuclear Retinoic Acid Receptor Binding Pyruvate Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Nucleus MRNA Cleavage And Polyadenylation Specificity Factor Complex	Nucleoplasm Chromatin Organization Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromosome, Telomeric Region Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Protein Localization To Organelle Chromosome Organization Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleosome Assembly Protein-containing Complex Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Protein Import Into Nucleus Rhythmic Process Negative Regulation Of Biosynthetic Process Chromosome Import Into Nucleus Telomere Organization Protein-DNA Complex Assembly Nucleosome Organization Regulation Of Macromolecule Biosynthetic Process Structural Constituent Of Chromatin Nuclear Telomere Cap Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Protein Localization To Chromosome Protein Localization To Nucleus Positive Regulation Of Macromolecule Metabolic Process Nucleosome Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Population Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Programmed Cell Death DNA Binding
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